贵阳市城区40岁以上女性初产年龄与代谢综合征相关性的横断面研究

Cross-sectional study on correlation between primiparity age and metabolic syndrome among women over 40 years old in Guiyang

目的分析贵阳市城区40岁以上女性初产年龄与代谢综合征(MS)患病率的关系。方法对贵阳市城区40岁以上女性进行随访,最终将4844名女性纳入横断面研究,分析初产年龄、初潮年龄、产次、年龄、哺乳等生育因素与MS患病率的关系。结果将女性按照初产年龄分为5组,小于20岁,20~<25岁,25~<30岁,30~<35岁,≥35岁,MS患病率分别为54.27%、49.73%、44.15%、41.44%、35.29%。经多因素Logistic回归分析后,初产年龄≥35岁组MS患病风险是<20岁组的0.477倍(OR=0.477,95%CI:0.236~0.964),为巨大胎母亲,收缩压(SBP)、舒张压(DBP)、空腹血糖、三酰甘油(TG)水平升高是MS患病的独立危险因素(P<0.05),高密度脂蛋白(HDL)水平升高是MS患病的独立保护因素(OR=0.113,95%CI:0.092~0.140,P<0.05)。结论贵阳市城区40岁以上女性初次生育年龄大于或等于35岁MS患病率最低,随着初产年龄的降低MS患病率升高。初产、生育年龄早可能会增加MS的患病风险。

Objective To understand the correlation between primiparity age and the prevalence of metabolic syndrome(MS)among women over 40 years old in urban areas of Guiyang.Methods Women over 40 years old in Guiyang were followed up and a total of 4844 women were included in the cross-sectional study.The correlation between primiparity age,menarche age,parity,age,lactation and other fertility factors and the prevalence of MS was analyzed.Results Women were divided into 5 groups according to primiparity age:<20 years old,20-<25 years old,25-<30 years old,30-<35 years old,≥35 years old,and the prevalence of MS was 54.27%,49.73%,44.15%,41.44%,35.29%,respectively.After multivariate Logistic regression analysis,the risk of MS in the primiparity age≥35 years old group was 0.477 times that of the women<20 years old group(OR=0.477,95%CI:0.236-0.964),being mother of macrosomia,elevated SBP,DBP,fasting blood glucose and TG levels were independent risk factors for MS(P<0.05).Elevated HDL level is an independent protective factor for MS(OR=0.113,95%CI:0.092-0.140,P<0.05).Conclusion The prevalence of MS is the lowest in the primiparity age≥35 years old group among women over 40 years old in Guiyang,and the prevalence of MS increased with the decrease of primiparity age.Primiparity and early birth age may increase the risk of MS.