期刊文献+

结直肠癌和脂肪代谢之间的关系 被引量:3

Correlation between colorectal cancer and fat metabolism
下载PDF
导出
摘要 结直肠癌是胃肠外科常见的恶性肿瘤,在我国的发病率和病死率也较高,但是其发病机制尚不十分明确。大量研究提示,结直肠癌和脂肪代谢关系密切,充分了解结直肠癌和脂肪代谢的关系尤为重要,或可有助于早期诊断和治疗结直肠癌,进而降低病死率,提高患者的生存率。本文旨在对现有脂肪代谢和结直肠发生、发展的机制研究进行综述,为后期研究提供参考。 Colorectal cancer is a commonly cancer in gastrointestinal surgery,which has a highly morbidity and mortality in China,but its pathogenesis is not very clear.A number of scientific evidences suggest that colorectal cancer is closely related to fat metabolism.Therefore,it is important to sufficiently understand the correlation between colorectal cancer and fat metabolism,which may help for early diagnosis and treatment of colorectal cancer,thereby reducing mortality and improving survival rate.The purpose of this article is to review the existing research on the mechanisms of fat metabolism and the occurrence and development of colorectal cancer,and to provide a reference for later research.
作者 张小丽 曾靓(综述) 张尊月 罗华友(审校) ZHANG Xiaoli;ZENG Liang;ZHANG Zunyue;LUO Huayou(Department of Gastrointestinal and Hernia Surgery,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650032,China;The NHC Key Laboratory of Drug Addiction Medicine,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650032,China)
出处 《重庆医学》 CAS 2020年第7期1176-1179,1183,共5页 Chongqing medicine
基金 云南省卫生厅内设机构项目(2017NS001) 中国健康促进基金会黎介寿院士项目(LJS-201707)。
关键词 结直肠肿瘤 脂肪代谢 分子机制 colorectal neoplasms fat metabolism molecular mechanism
  • 相关文献

参考文献1

二级参考文献11

  • 1Lenka Doubravska,Michaela Krausova,Dietmar Gradl,Martina Vojtechova,Lucie Tumova,Jan Lukas,Tomas Valenta,Vendula Pospichalova,Bohumil Fafilek,Jiri Plachy,Ondrej Sebesta,Vladimir Korinek.Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling[J].Cellular Signalling.2011(5)
  • 2Xinxin Gao,Natalia Arenas-Ramirez,Suzie J. Scales,Rami N. Hannoush.Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes[J].FEBS Letters.2011(15)
  • 3Andrea Reinartz,Josef Ehling,Andrea Leue,Christian Liedtke,Ursula Schneider,Jürgen Kopitz,Thomas Weiss,Claus Hellerbrand,Ralf Weiskirchen,Ruth Knüchel,Nikolaus Gassler.Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis[J].BBA - Molecular and Cell Biology of Lipids.2010(9)
  • 4Ashley M. Goss,Ying Tian,Tadasuke Tsukiyama,Ethan David Cohen,Diane Zhou,Min Min Lu,Terry P. Yamaguchi,Edward E. Morrisey.Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut[J].Developmental Cell.2009(2)
  • 5Hiroki Kuniyasu,Dipak Panigrahy.The Roles of Dietary PPAR γ Ligands for Metastasis in Colorectal Cancer[J].PPAR Research.2008
  • 6Nikolaus Gassler,Wilfried Roth,Benjamin Funke,Armin Schneider,Frank Herzog,Jens J.W. Tischendorf,Kerstin Grund,Roland Penzel,Ignacio G. Bravo,John Mariadason,Volker Ehemann,Jaromir Sykora,Tobias L. Haas,Henning Walczak,Tom Ganten,Hanswalter Zentgraf,Peter Erb,Angel Alonso,Frank Autschbach,Peter Schirmacher,Ruth Knüchel,Jürgen Kopitz.Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing[J].Gastroenterology.2007(2)
  • 7Tao Tang,Kyle Rector,Corey D. Barnett,Catherine D. Mao.Upstream open reading frames regulate the expression of the nuclear Wnt13 isoforms[J].Biochemical and Biophysical Research Communications.2007(4)
  • 8Hans Clevers.Wnt/β-Catenin Signaling in Development and Disease[J].Cell.2006(3)
  • 9Tony J.C. Harris,Mark Peifer.Decisions, decisions: β-catenin chooses between adhesion and transcription[J].Trends in Cell Biology.2005(5)
  • 10Kjersti Flatmark,Gunhild M M?landsmo,Marita Martinsen,Heidi Rasmussen,?ystein Fodstad.Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice[J].European Journal of Cancer.2004(10)

共引文献5

同被引文献32

引证文献3

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部