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白细胞介素-10与2型糖尿病发病风险的关联性 被引量：6

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摘要 2型糖尿病(T2DM)发病过程常伴随白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)及肿瘤坏死因子-α(TNF-α)等细胞因子水平的改变,这些细胞因子能抑制胰岛素分泌、诱导β细胞凋亡及引起外周胰岛素抵抗,与T2DM的发生密切相关。白细胞介素-10(IL-10)作为一种重要的抑制性细胞因子,能够抑制IL-1β、IL-6、IFN-γ及TNF-α等细胞因子的合成以及作用的发挥,保护胰岛功能和改善外周胰岛素抵抗,在T2DM的发生发展过程中起着重要作用,本文对IL-10及其基因多态性与T2DM发生风险的关系进行综述。
作者 吴坤荣(综述) 李晓黎 李妍(审校)
机构地区 山东大学药学院 山东第一医科大学药学院 山东第一医科大学第一附属医院药学部
出处 《卫生研究》 CAS CSCD 北大核心 2020年第2期331-335,共5页 Journal of Hygiene Research
基金 国家重点研发计划(No.2017YFC0910004)。
关键词 2型糖尿病 遗传多态性 白细胞介素-10
分类号 R587.1 [医药卫生—内分泌]
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共引文献20

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二级引证文献22

卫生研究
2020年 第2期

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