深圳市罗湖区女性HPV筛查阳性感染与宫颈病变关系

Analysis of the relationship between HPV positive infections and cervical lesions in female population in Luohu District Shenzhen

目的探讨女性人乳头瘤病毒(HPV)感染与宫颈病变的关系,为宫颈病变的防治提供依据。方法对本院2016年11月1日至2018年10月31日筛查HPV阳性病例资料进行回顾性分析,同时行TCT(液基细胞学)检查,以病理检查结果作为诊断标准。结果 2622例HPV阳性患者纳入本研究,病理检查结果阳性有204例。有2030例单一HPV感染,592例多重感染,单一感染中病理阳性的病例均为高危型HPV感染;HPV感染最多的是31-40岁组,为38.98%(1022/2622),最少的是>60岁组,是2.02%(53/2622),但是,>60岁患者中宫颈阳性病变最多,达22.6%;TCT检查616例为阳性,其中宫颈病理阳性有131例(131/616,21.3%);高危HPV诊断准确度为8.3%(144/1742),TCT准确度为21.3%(131/616),两者比较差异有统计学意义(P<0.01)。结论深圳罗湖区女性HPV高危型感染宫颈病变率高,不同年龄组宫颈病变阳性最多的HPV亚型不同,TCT对于宫颈病变的诊断准确度高于HPV筛查。

Objective To investigate the relationship between female HPV infection and cervical lesions,in order to provide a practical basis for the district hospital to prevent and treat HPV infection and cervical cancer.Methods Retrospective analysis was performed on the data of HPV-positive cases screened from November 1,2016 to October 31,2018,and TCT(liquid-based cytology)examination was performed at the same time.The results of pathological examination were used as the diagnostic criteria.Results 2622 HPV-positive patients were included in the study,of which204 were pathologically positive.There were 2030 single HPV infections and 592 multiple infections.Patients with a positive pathological outcome in a single infection are all high-risk HPV infections.The most HPV infections were in the 31 to 40-year-old group,with 38.98%(1022/2622),and the least were in the> 60-year-old group,which was2.02%(53/2622),but the most positive cervical lesions were>60 years old patients,which was 22.6%.TCT was positive in 616 cases,of which 131 were positive in cervical pathology(131/616,21.3%);high-risk HPV diagnosis accuracy was 8.3%(144/1742),and TCT accuracy was 21.3%(131/616),both The difference was statistically significant(P<0.01).Conclusion Women with high-risk HPV infection have a high rate of cervical lesions in Shenzhen Luohu District,and the HPV subtypes with the most positive cervical lesions in different age groups are different.The diagnostic accuracy of TCT for cervical lesions is higher than HPV screening.