摘要
目的:观察自拟健脾化湿方对类风湿性关节炎患者类风湿因子及氧化应激指标的影响。方法:将120例类风湿性关节炎患者采用系统随机抽样法分为实验组与对照组各60例,对照组予以单纯西药治疗,实验组加服自拟健脾化湿方。比较两组患者治疗12周后的临床疗效,以及治疗前、治疗12周后中医主要证候积分、血清类风湿因子、关节液炎性因子[C反应蛋白(CRP)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)]水平变化。结果治疗12周后,实验组患者的临床总有效率明显高于对照组(P<0.05);两组患者关节肿胀、疼痛、屈伸不利、晨僵、肢冷畏寒积分均较治疗前降低,且实验组明显低于对照组(P均<0.05);两组患者类风湿因子、CRP均较治疗前降低,实验组低于对照组,IL-4、IL-10均较治疗前升高,实验组高于对照组(P均<0.05);两组患者SOD水平均较治疗前升高,实验组高于对照组,MDA、NO均较治疗前降低,实验组低于对照组(P均<0.05)。结论:自拟健脾化湿方联合西药治疗类风湿性关节炎疗效确切,可有助于缓解炎症,对氧化/抗氧化系统具有调控作用。
Objective:To evaluate the effects of Self-made Jianpi Huashi Recipe on rheumatoid factor and oxidative stress for patients with rheumatoid arthritis.Methods:120 patients with rheumatoid arthritis were divided into experimental group and controlled group according to the system randomization,with 60 in each group.The controlled group was treated with western medicine alone,and the experimental group was additionally given Self-made Jianpi Huashi Recipe.The clinical efficacy after 12 weeks of treatment,and the main TCM syndromes scores and levels of serum rheumatoid factors,joint fluid inflammatory factors [C-reactive protein(CRP),interleukin-4(IL-4),interleukin-10(IL-10)] and oxidative stress indexes [superoxide dismutase(SOD),malondialdehyde(MDA),nitric oxide(NO)] before treatment and after 12 weeks of treatment were compared between the two groups.Results:After 12 weeks of treatment,the total clinical effective rate in the experimental group was significantly higher than that in the controlled group(P < 0.05).The scores of joint swelling,pain,inhibited bending and stretching,morning stiffness and extreme chilliness in the two groups were decreased compared with those before treatment,and the scores in the experimental group were significantly lower than those in the controlled group(all P < 0.05).The levels of rheumatoid factors and CRP in the two groups were decreased compared with those before treatment,and the levels in the experimental group were lower than those in the controlled group,and the levels of IL-4 and IL-10 were increased compared with those before treatment,and the levels in the experimental group were higher than those in the controlled group(all P < 0.05).The SOD level in the two groups was increased compared with that before treatment,and the level in the experimental group was higher than that in the controlled group,and the levels of MDA and NO were decreased compared with those before treatment,and the levels in the experimental group were lower than those in the controlled group(all P < 0.05).Conclusion:Self-made Jianpi Huashi Recipe has exact efficacy in the treatment of rheumatoid arthritis,and it can help relieve inflammation and regulate the oxidation/antioxidant system.
作者
陈佩钰
CHEN Peiyu(Department of Internal Medicine,Youxian District Hospital of Traditional Chinese Medicine of Mianyang City,Mianyang Sichuan 621000,China)
出处
《四川中医》
2020年第3期99-102,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
四川省卫生和计划生育委员会资助项目(16PJ678)。
关键词
健脾化湿方
类风湿性关节炎
类风湿因子
氧化应激
Jianpi Huashi Recipe
Rheumatoid arthritis
Rheumatoid factors
Oxidative stress