中西医结合疗法对慢性盆腔炎患者炎症因子及血液流变学的影响观察

Effect of Integrated Chinese and Western Medicine on Inflammatory Factors and Hemorheology for Patients with Chronic Pelvic Inflammatory Disease

目的:观察中西医结合疗法对慢性盆腔炎(CPID)患者炎症因子及血液流变学的影响。方法:选择我院2017年7月~2017年12月慢性盆腔炎患者100例,信封法随机分为两组,对照组50例采用西医药物治疗;中西医联合组50例采用中药口服、物理治疗、穴位贴敷等联合治疗。治疗前、疗程结束后评价疗效,并检测患者炎症因子、相关免疫细胞因子、血液流变学指标。结果:治疗后两组TNF-α、IL-6、CRP、全血高切粘度、全血低切粘度、血浆粘度、纤维蛋白原水平较治疗前显著降低,IL-2水平、CD4^+、CD4^+/CD8^+比值较治疗前显著提高,与治疗前比较差异有统计学意义(P<0.05)。联合组治疗后TNF-α、IL-6、CRP、全血高切粘度、全血低切粘度、血浆粘度、纤维蛋白原水平均低于对照组,IL-2水平、CD4^+、CD4^+/CD8^+比值高于对照组;差异均有统计学意义(P<0.05)。联合组痊愈率38.00%,有效率56.00%,总有效率94.00%;对照组痊愈率18.00%,有效率62.00%,总有效率80.00%,两组总有效率比较差异有统计学意义(P<0.05)。结论:中西医结合疗法可活血化瘀,显著下调体内炎性发应,减轻盆腔炎症刺激,提高机体免疫功能,改善体内血液粘滞度,促进CPID患者临床症状的全面改善。

Objective:To observe the effectsof TCM and western medicine combined therapy on inflammatory factors and hemorheology for patients with chronic pelvic inflammatory disease(CPID).Methods:100 patients with chronic pelvic inflammation from July 2017 to December 2017 were selected in our hospital.The envelope method was randomly divided into two groups,and 50 patients in the controlled group were treated with western medicine.Fifty cases were treated by oral Chinese medicine,physical therapy and acupoint sticking.Efficacy was evaluated before treatment and after treatment,and inflammatory factors,related immune cytokines and hemorheology indexes were measured.Results:After treatment,TNF-a,IL-6,CRP,high incised viscosity of whole blood,low incised viscosity of whole blood,plasma viscosity and fibrinogen levels of the two groups were significantly reduced compared with those before treatment,and IL-2 level,CD4+,CD4+/CD8+ ratio were significantly increased compared with those before treatment,showing statistically significant difference(P < 0.05).After treatment,TNF-a,IL-6,CRP,high cut viscosity of whole blood,low cut viscosity of whole blood,plasma viscosity and fibrinogen raw water of the combined group were lower than the controlled group on average,and IL-2 level,CD4+,CD4+/CD8+ ratio were higher than the controlled group.The differences were statistically significant(P < 0.05).In the combined group,the recovery rate was 38.00%,the effective rate was 56.00% and the total effective rate was 94.00%.The recovery rate of the controlled group was 18.00%,the effective rate was 62.00%,and the total effective rate was 80.00%,and the difference between the two groups was statistically significant(P < 0.05).Conclusion:Combined Chinese and western medicine can promote blood circulation and blood stasis,significantly reduce inflammatory response in vivo,reduce pelvic inflammatory stimulation,improve the body’s immune function,improve blood viscosity in vivo,and promote the overall improvement of clinical symptoms in CPID patients.