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曲美他嗪联合血管紧张素Ⅱ受体阻断剂治疗冠心病心力衰竭患者的效果

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摘要 目的观察曲美他嗪联合血管紧张素Ⅱ(AngⅡ)受体阻断剂治疗冠心病心力衰竭患者的效果。方法选取2017年10月至2018年12月修武县人民医院收治的冠心病心力衰竭患者92例,按照随机数表法分为对照组与联合组,各46例。对照组接受AngⅡ受体阻断剂治疗,联合组接受曲美他嗪+AngⅡ受体阻断剂治疗。对比两组治疗效果及治疗前后心功能[左心室射血分数(LVEF)、左心室收缩末期内径(LVESd)、二尖瓣舒张早期峰值流速与舒张晚期二尖瓣血流速度比值(E/A)]、血浆脑钠肽(BNP)水平。结果治疗8周后,联合组总有效率(95.65%)较对照组(80.43%)高,联合组LVEF、E/A较对照组高,LVESd较对照组小(均P<0.05);治疗4、8周后,联合组血浆BNP水平较对照组低(均P<0.05)。结论曲美他嗪联合AngⅡ受体阻断剂治疗冠心病心力衰竭,可显著强化治疗效果,下调血浆BNP水平,改善心功能。
作者 赵海杰
出处 《河南医学研究》 CAS 2020年第6期1065-1066,共2页 Henan Medical Research
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