血清可溶性α-Klotho在慢性肾脏病中生物学作用的研究进展

Research progress on the biological role of serum soluble α-Klotho in chronic kidney diseases

α-Klotho是一种抗衰老蛋白,研究报道其通过与成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)结合成为成纤维细胞生长因子23(fibroblastic growth factor-23,FGF23)的跨膜协同受体,进而调节FGF23/FGFR1/Klotho信号传导,在平衡体内钙磷代谢和抗衰老中起关键作用。近期有关血清可溶性α-Klotho(sKL)的研究受到了广泛的关注,研究发现在慢性肾脏病(CKD)中血清sKL能调节多种信号通路,发挥保护足细胞结构、抑制氧化应激、抑制组织纤维化和调节钙磷代谢等作用,表明血清sKL在保护CKD患者肾功能、延缓病情进展以及作为生物学标志物方面的作用。

α-Klotho is an anti-aging protein,which has been reported to bind with fibroblast growth factor receptor-1(FGFR1)to become a transmembrane co-receptor of fibroblastic growth factor-23(FGF23),thereby mediating FGF23/FGFR1/Klotho signaling to play a key role in anti-aging and balance calcium and phosphorus metabolism.Recent studies on serum solubleα-Klotho are concerned extensively.Studies have shown that serum solubleα-Klotho(sKL)regulates multiple signaling pathways in chronic kidney diseases(CKD)to protect the structure of podocytes,inhibit oxidative stress,reduce tissue fibrosis and regulate the metabolism of calcium and phosphorus.It plays an important role in protecting renal function in CKD patients,delaying disease progression,and acting as a biomarker.