308nm准分子激光联合CO2点阵激光治疗稳定期白癜风的疗效观察

Efficacy of 308-nm excimer laser combined with fractional CO2 laser in treatment of stable vitiligo

目的:观察308nm准分子激光联合CO2点阵激光对于稳定期白癜风的治疗效果及安全性。方法:选取118例稳定期白癜风患者,使用随机数字表法分为观察组和对照组,观察组59例(皮损总数328处),对照组59例(皮损总数319处)。观察组采用308 nm准分子激光联合CO2点阵激光治疗,对照组单纯采用308 nm准分子激光治疗。治疗3个月后,比较两组疗效及不良反应发生情况。结果:治疗后,观察组及对照组总有效率分别为89.94%和84.64%,两组总有效率比较,差异有统计学意义(χ^2=6.59,P=0.014),两组不良反应总发生率分别为23.34%和22.15%,两组比较差异无统计学意义(χ^2=1.29,P=0.088)。结论:308nm准分子激光联合CO2点阵激光对于稳定期白癜风具有良好的疗效。

Objective:To evaluate the efficacy and safety of fractional CO2 laser combined with 308-nm excimer laser for the treatment of stable vitiligo.Methods:A total of 118 patients of stable vitiligo were enrolled in this trial.Patients were assigned into the treatment group(n=59,328 lesions)and control group(n=59,319 lesions)using a random digital table method.The treatment group was treated with fractional CO2 laser combined with 308-nm excimer laser,while the control group was treated with 308-nm excimer laser alone.Efficacy and adverse reactions were evaluated after 3 months of consecutive treatments.Results:After the treatments,the total effective rates were higher in the treatment group than that in the control group(89.94%vs.84.64%,χ^2=6.59,P=0.014).The rate of the adverse reactions did not differ between the two groups(23.34%vs.22.15%,χ^2=1.29,P=0.088).Conclusion:308-nm excimer laser combined with fractional CO2 laser is safe and effective for patients with stable vitiligo.