丹参酮ⅡA磺酸钠和比索洛尔治疗冠心病心绞痛的效果及对血清PAI-1、Lp-PLA2的影响

Therapeutic effects of sulfotanshinoneⅡA sodium injection combined with bisoprolol on angina pectoris due to coronary heart disease and their influence on the serum levels of PAI-1 and Lp-PLA2 of patients

目的研究丹参酮ⅡA磺酸钠联合比索洛尔对冠心病心绞痛的治疗效果及对血清纤溶酶原激活剂抑制物-1(plasminogen activatorinhibitor-1,PAI-1)、脂蛋白相关磷脂酶A2(Lipoprotein-associated phospholipase A2,Lp-PLA2)的影响。方法112例冠心病心绞痛患者随机分为对照组和观察组,每组56例。对照组给予比富马酸索洛尔片治疗。观察组在对照组的基础上给予丹参酮ⅡA磺酸钠注射液。比较2组患者治疗前后临床疗效、心电图改善情况、血脂水平[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]和心肌酶[磷酸肌酸激酶(CK)、磷酸肌酸酶同工酶(CK-MB)、乳酸肌氢酶(LDH)、羟丁酸脱氢酶(HBDH)]水平,并比较2组血清中PAI-1和Lp-PLA2水平,记录不良反应情况。结果观察组的总有效率心电图改善率显著高于对照组(P<0.05)。观察组治疗后的LDL-C、TG、TC水平显著低于对照组(P<0.05),HDL-C水平显著高于对照组(P<0.05),心肌酶指标(CK、CK-MB、LDH及HBDH)的水平显著低于对照组(P<0.05)。治疗后2组PAI-1和Lp-PLA2水平均显著下降(P<0.05),且治疗后观察组PAI-1和Lp-PLA2水平显著低于对照组(P<0.05)。2组的总不良反应率差异无统计学意义(P>0.05)。结论丹参酮ⅡA磺酸钠注射液联合比索洛尔治疗冠心病心绞痛疗效显著,具有调脂作用,不会增加不良反应风险,并能显著下调血清中Lp-PLA2、PAI-1含量,缓解炎症,减少血栓形成的机制治疗冠心病心绞痛。

Objective To investigate the Therapeutic effects of sulfotanshinoneⅡA sodium injection combined with bisoprolol on angina pectoris due to coronary heart disease(CHD)and their influence on the serum levels of plasminogen activatorinhibitor-1(PAI-1)and lipoprotein-associated phospholipase A2(Lp-PLA2)of patients with CHD.Methods A total of 112 patients with CHD patients who were treatin our hospital from October 2017 to October 2018 were randomly divided into control and observation group,with 56 patients in each group.The patients in control group were treated by oral bisoprolol tablets,however,thepatients in observation group,on thebasis of control group,were treated by sulfotanshinoneⅡA sodium injection.The therapeutic effects,and the changes of TG,TC,LDL-C,HDL-C,CK,CK-MB,LDH,HBDH,PAI-1,PLA2,as well as adverse reactions were observed and compared between the two groups.Results The total effective rate and improvement rate of ECG in observation group was significantly higher than those in control group(P<0.05).After treatment the serum levels of LDL-C,TGand TC in observation group were significantly lower than those in control group(P<0.05),however,the HDL-C levels in observation group were significantly higher than those in control group(P<0.05).After treatment the myocardial enzymes indexes including CK,CK-MB,LDH and HBDH in observation group were significantly lower than those in control group(P<0.05),and the levels of PAI-1 and Lp-PLA2 in both groups were significantly decreased after treatment(P<0.05),moreover,which in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion SulfotanshinoneⅡA sodium injection conbined with bisoprolol has obvious therapeutic effects on angina pectoris due to CHD,which can improve the ECG indexes and regulate the lipid,without increasing the risk of adverse reactions,which can significantly decrease the serum levels of PAI-1 and Lp-PLA2,which can relive inflammation and decrease thrombopoiesis.