肝动脉化疗栓塞术联合PEI微创对原发性肝癌的效果及相关因素分析

Therapeutic effects transcatheter arterial chemoembolization combined with minimally invasive PEI on primary hepatocellular carcinoma and its related factors

目的分析肝动脉化疗栓塞(TACE)联合无水酒精消融术(PEI)微创介入疗法与单独肝动脉化疗栓塞术治疗肝癌原发性肝癌疗效及相关影响因素。方法152例原发性肝癌患者按照手术治疗方式分为对照组和观察组,每组76例。对照组患者给予肝动脉化疗栓塞术治疗,观察组患者使用肝动脉化疗栓塞术配合PEI微创介入治疗;分析2组患者临床疗效、甲胎蛋白(AFP)值变化、术后并发症发生率、患者焦虑自评量表(SAS)评分以及对患者的满意度方面调查情况。结果观察组总有效率高于对照组(P<0.05)。治疗后观察组AFP值平均下降率,AFP下降超过50%者及恢复正常者均优于对照组(P<0.05)。观察组栓塞后综合征、局部感染、胆瘘发生率均低于对照组(P<0.05),肩背部疼痛发生率高于对照组(P<0.05)。观察组治疗后SAS评分低于对照组,患者满意度高于对照组(P<0.05)。结论肝动脉化疗栓塞联合PEI介入疗法治疗原发性肝癌较单纯采用肝动脉化疗栓塞术治疗效果理想,且安全性高。在减少术后并发症发生、改善患者情绪、提高其生活质量及患者满意度等方面,优势明显,值得在临床推广。

Objective To investigate the therapeutic effects transcatheter arterial chemoembolization(TACE)combined with minimally invasive PEI on primary hepatocellular carcinoma(HCC)and its related factors.Methods A total of 152 patients with primary HCC who were admitted and treated in our hospital from December 2016 to October 2018 were enrolled in thestudy,who were divided into control group and observation group according to the surgical ways,with 76 cases in each group.Thepatients in control group were treated by TACE,however,the patients in observation group were treated by PACE combined with PEI minimally invasive intervention.The clinical efficacy,and the changes of AFP,incidence rate of postoperative complications,SAS score and satisfaction degree of patients were observed and compared between the two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment the decrease rate of AFP mean value in observation group was superior to that in control group(P<0.05).Moreover the incidence rates of in post embolizatiou syndrome,local infection and biliary fistula in observation group were significantly lower than those in control group(P<0.05),but the incidence rate of shoulder and back pain in observation group was significantly higher than that in control group(P<0.05).In addition the SAS scores in observation group were significantly lower than those in control group(P<0.05),but the satisfaction degree of patients in observation group was significantly higher than that in control group(P<0.05).Conclusion HACE combined with PEI interventional therapy is more effective and safe than hepatic arterial chemoembolization alone in treatment of HCC,which has obvious advantages in reducing postoperative complications,improving patients’emotion,improving the life quality and satisfaction degree of patients,therefor,it is worth popularizing in clinical practice.