摘要
目的:探究阿奇霉素联合红霉素对肺炎支原体肺炎(MPP)患儿血清中TNF-α、IL-6、IL-8及IL-10浓度的影响。方法:选取某院收治的肺炎支原体肺炎患儿155例,随机分为阿奇霉素治疗组(58例)、红霉素治疗组(55例)及阿奇霉素联合红霉素治疗组(联合治疗组42例)。比较3组患儿治疗前后炎性细胞因子IL-6、IL-8、IL-10及TNF-α水平和免疫因子IgG、IgM及IgA的变化差异,评估3组患儿治疗有效率。结果:3组患儿治疗前后IL-6、IL-8、IL-10及TNF-α变化组间比较存在明显统计学差异,联合治疗组明显高于阿奇霉素及红霉素单药治疗组(P<0.05);联合治疗组治疗前后IgG、IgA及IgM水平变化均高于单药治疗组(P<0.05);联合治疗组治疗有效率优于单药治疗组,3组比较差异有统计学意义(P<0.05)。结论:阿奇霉素与红霉素联合用药可明显降低MPP患儿的炎性指标,加快其康复进程。
Objective:To investigate the effect of azithromycin combined with erythromycin on serum concentrations of TNF-α,IL-6,IL-8 and IL-10 in children infected with mycoplasma pneumoniae pneumonia(MPP).Methods:155 children with MPP were randomly divided into an azithromycin group(58 cases),an erythromycin group(55 cases)and an azithromycin combined with erythromycin group(42 cases).Changes of inflammatory cytokines(IL-6,IL-8,IL-10 and TNF-α)and immune globulin(IgG,IgM and IgA)before and after treatment were compared among the three groups.Results:There were significant differences in change of IL-6,IL-8,IL-10 and TNF-αbefore and after treatment between the 3 groups,with changes in azithromycin combined with erythromycin group being more significant than the other two groups(P<0.05).The levels of IgG,IgA and IgM in the combination treatment group before and after treatment were significantly higher than those in the monotherapy group(P<0.05).The effective rate of the combination treatment group was higher than that of the monotherapy group(P<0.05).Conclusion:The combination of azithromycin and erythromycin can significantly reduce the inflammatory index of MPP children and accelerate their recovery.
作者
朱玉林
高慧
方露露
丁圣刚
ZHU Yu-lin;GAO Hui;FANG Lu-lu(Department of Paediatrics,The First Affiliated Hospital of Anhui Medical University,Hefei, Anhui 230022, China)
出处
《淮海医药》
CAS
2020年第2期111-113,116,共4页
Journal of Huaihai Medicine
关键词
肺炎
支原体
阿奇霉素
红霉素
炎性细胞因子
儿童
Pneumonia,mycoplasma pneumoniae
Azithromycin
Erythromycin
Inflammatory cytokines
Child