裂隙淋巴细胞对百日咳的诊断价值

Diagnostic value of cleaved lymphocytes for pertussis

目的探讨外周血涂片中裂隙淋巴细胞对百日咳的诊断价值。方法选择该院80例疑似百日咳患儿为研究对象,按照百日咳杆菌核酸检测结果将其分为百日咳阳性组和百日咳阴性组,每组40例;分析两组患儿白细胞(WBC)计数、淋巴细胞百分比(LYMPH%)、裂隙淋巴细胞阳性率的差异,同时比较各指标对百日咳诊断的特异度和灵敏度。结果百日咳阳性组WBC计数、LYMPH%、裂隙淋巴细胞的阳性率高于百日咳阴性组,差异有统计学意义(P<0.05);裂隙淋巴细胞诊断百日咳的特异度为97.5%,明显高于WBC计数、LYMPH%的特异度,差异有统计学意义(P<0.05);裂隙淋巴细胞诊断百日咳的灵敏度为52.5%,与WBC计数、LYMPH%比较,差异有统计学意义(P<0.05)。结论临床上疑似百日咳患儿,可建议进行WBC形态学检查。血涂片中出现裂隙淋巴细胞提示百日咳感染,临床医生可通过完善百日咳的相关检查以明确诊断,有助于缩短诊疗周期,节约医疗成本,为基层医院百日咳的早期诊治提供依据。

Objective To investigate the diagnostic value of cleaved lymphocytes in peripheral blood for pertussis.Methods A total of 80 children with suspected pertussis in this hospital were selected,and equally divided into the pertussis-positive group and the pertussis-negative group according to the results of the pertussis bacillus nucleic acid test.At the same time,the differences of white blood cell(WBC)count,lymphocyte percentage(LYMPH%)and cleaved lymphocytes positive rate between the two groups were compared,the specificity and sensitivity of each index for the diagnosis of pertussis were analyzed.Results The positive rate of WBC count,LYMPH%and cleaved lymphocytes in the pertussis-positive group were significantly higher than that of the pertussis-negative group(P<0.05).The specificity of cleaved lymphocytes in diagnosis pertussis was 97.5%,which was significantly higher than that of the specificity of WBC and LYMPH%(P<0.05).The sensitivity of cleaved lymphocytes was 52.5%,which had the statistically differences with WBC and LYMPH%(P<0.05).Conclusion Children with suspected pertussis could be suggested testing morphological examination of WBC.Cleaved lymphocytes in blood smear have revealed pertussis.Doctors could conduct related tests to identify the diagnosis,which could shorten the diagnosis and treatment time,save the cost and provide the basis for the treatment of primary hospital.