重度子痫前期患者血清GAS6与其他炎症因子的相关性研究

The correlation between the growth arrest-specific protein 6 and other inflammatory factors in patients with severe preeclampsia

目的探讨重度子痫前期患者血清生长停滞特异性基因产物6(GAS6)的水平与其他炎症因子的相关性。方法回顾性选取2018年1月-10月期间我院分娩的产妇133例,其中重度子痫前期产妇77例为病例组,正常妊娠产妇56例为对照组。酶联免疫吸附试验检测血清GAS6、白细胞介素6(IL-6)、白细胞介素10(IL-10)、白细胞介素18(IL-18)水平,生化分析仪检测C反应蛋白(CRP),分析2组各指标差异及有差异的指标与GAS6的相关性。结果病例组收缩压、舒张压高于对照组,孕周少于对照组,血清GAS6以及IL-10水平降低,而IL-6、IL-18水平高于对照组(P<0.05)。血清GAS6水平变化与IL-6水平呈负相关。结论重度子痫前期患者血清GAS6参与炎症反应,发挥抗炎因子的作用,其血清浓度与炎症反应严重程度存在相关性。

Objective To investigate the correlation between the serum level of growth arrest-specific protein 6(GAS6) and other inflammatory factors in patients with severe preeclampsia.Methods A total of 133 cases of pregnant women hospitalized in our hospital were retrospectively chosen from January to October of 2018.Patients were divided into two groups.The case group included 77 cases of patients with severe preeclampsia.The control group included 56 healthy pregnant women.The serum levels of GAS6,interleukin 6(IL-6),IL-10 and IL-18 were measured by enzyme-linked immune sorbent assay.C reactive protein(CRP) was measured by biochemical analyzer.The correlation of the above indexes were analyzed in two groups of patients.Results The systolic blood pressure and diastolic blood pressure were higher in the severe preeclampsia group than those of the control group,and the gestational age was less in the severe preeclampsia group than that of the control group.The serum levels of GAS6 and IL-10 were significantly lower in the severe preeclampsia group than those in the control group(P<0.05),while the levels of IL-6 and IL-18 were higher than those in the control group(P<0.05).The serum GAS6 level was negatively correlated with IL-6.Conclusion In severe preeclampsia patients,the serum GAS6 is involved in inflammatory reaction and plays the role of anti-inflammatory factors.The serum level of GAS6 is related with the severity of inflammatory reaction.