红豆杉多糖对糖尿病大鼠的降血糖作用及机制研究

Study on the hypoglycemic effect of taxus polysaccharides on diabetic rats and its mechanism

目的:探讨红豆杉多糖降血糖作用及机制。方法:STZ诱导大鼠糖尿病模型,分为糖尿病模型组、阳性药物对照组和红豆杉多糖组,另设阴性对照组,每组10只。阳性对照组和红豆杉多糖组分别灌服二甲双胍和红豆杉多糖,另两组灌服生理盐水。连续给药30d。检测大鼠胸腺、脾脏组织T-SOD、GSH-PX及MDA水平。结果:红豆杉多糖可降低糖尿病大鼠血糖,提高脾脏、胸腺组织T-SOD、GSH-PX活力,降低MDA含量。结论:红豆杉多糖可通过影响大鼠主要免疫器官抗氧化系统,发挥降血糖作用。

Objective:To investigate the hypoglycemic effect and mechanism of taxus polysaccharide.Methods:Forty adult SD rats were divided into the diabetes model group,the positive drug control group,the taxus polysaccharide group and the negative control group,with 10 rats in each group.The diabetic rat model was established by intraperitoneal injection of streptozotocin(STZ).The positive control group and the taxus polysaccharide group were given metformin and taxus polysaccharide,respectively,and the other two groups were given normal saline for 30 consecutive days.The levels of T-SOD,GSH-PX and MDA in rat thymus and spleen tissues were detected.Results:The activity of T-SOD and GSH-PX in thymus and spleen tissues of rats in the taxus polysaccharides group was significantly increased,while the content of MDA was significantly decreased,the difference was statistically significant.Conclusion:Taxus polysaccharides can improve the activity of T-SOD and GSH-PX in thymus and spleen tissues,reduce the content of MDA,and play a role in lowering blood glucose.