新生儿IRAKM基因多态性与早产的相关性研究

Study on the relationship between IRAKM gene polymorphism and preterm birth

目的研究新生儿白介素1受体相关激酶M(IRAKM)基因多态性与早产的关系。方法选取2017年1月-2018年12月在浙江省台州医院就诊的妊娠妇女1 300例,随机选取其中300例早产儿作为早产儿组和50例非早产儿作为对照组,统计2组新生儿一般资料。检测2组新生儿血清IRAKM mRNA的表达量,并检测IRAKM基因型,分析新生儿IRAKM基因多态性与早产的相关性。结果 2组新生儿母亲平均年龄、母亲分娩史、母亲文化程度、性别比较,差异无统计学意义(均P>0.05)。早产儿组血清中IRAKM mRNA表达量低于对照组,差异具有统计学意义(P<0.05)。2组新生儿IRAKM+22148位点基因型频率、等位基因频率比较差异具有统计学意义(均P<0.05)。Logistic回归分析结果显示,携带基因G为早产发生的危险因素。结论新生儿IRAKM+22148位点基因多态性与早产具有一定的相关性,携带等位基因G可能是发生早产的易感基因。

Objective To study interleukin-1 receptor-related kinase M(IRAKM) gene polymorphism in neonates and its relevance to premature delivery. Methods From January 2017 to December 2018, 1 300 pregnant women in our hospital were selected. A total of 300 premature infants were randomly selected as the preterm group and 50 as the control group. The general data of the two groups were collected, the expression of serum IRAKM mRNA in the two groups was detected, the IRAKM genotype was detected, and the correlation between the IRAKM gene polymorphism and preterm birth was analyzed. Results There was no significant difference between the two groups(all P>0.05). The expression of IRAKM mRNA in premature group was lower than that in control group, the difference was statistically significant(all P<0.05). There was significant difference in the frequency of IRAKM+22148 genotype and allele in preterm birth(all P<0.05). The results of logistic regression analysis showed that g was the risk factor of premature delivery. Conclusion The polymorphism of IRAKM+22148 locus in neonates is associated with premature delivery, and carrying allele G may be a susceptible gene for premature delivery.