摘要
在氯化胆碱和氯化锌组成的深共融溶剂中,以2-氨基苯乙酮和芳香炔烃为原料,通过环化偶联反应,合成了一系列2,4-二取代喹啉衍生物;当n(氯化胆碱)∶n(氯化锌)=1∶2,反应温度为80℃时,反应3 h即获得高达98%的产率.该方法无需额外添加催化剂,而且反应条件温和、操作简单、底物范围较广泛.
In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1∶2, the yield up to 98% was achieved at 80 ℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.
作者
陈国庆
谢宗波
刘一帅
孟佳
乐长高
Chen Guoqing;Xie Zongbo;Liu Yishuai;Meng Jia;Le Zhanggao(State Key Laboratory,of Nuclear Resources and Environment,East China University of Technology,Nanchang 330013;Department of Applied Chemistry,East China University of Technology,Nanchang 330013)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第1期156-161,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21462001,11765002)
江西省科技计划(Nos.20161BCB24006,20181BAB203019)资助项目。
关键词
深共融溶剂
氯化胆碱
氯化锌
环化偶联
2
4-二取代喹啉
deep eutectic solvent
choline chloride
zinc chloride
cyclization coupling
2,4-disubstituted quinoline
