家畜肠道微生物代谢组学研究进展

Advances of Study on Livestock Intestinal Microbial Metabolites

家畜肠道微生物群落之间、微生物与宿主之间不断相互作用,形成动物肠道内复杂的微生物生态环境。肠道微生物及其代谢产物对维持家畜正常生长发育、营养代谢、繁殖性能等方面有着重要作用。微生物-脑-肠轴是中枢神经系统和肠道微生物之间的双向调节渠道。利用代谢组学对微生物代谢物进行检测能对微生物多样性分析数据进行补充,从而进一步揭示肠道微生物与宿主之间相互作用关系。该文综述了家畜肠道微生物代谢物的种类、代谢组学在肠道微生物研究中的应用以及肠道微生物代谢物对家畜动物的影响等内容,有助于了解微生物代谢物与家畜之间的相互作用以及研究的现状。

The complex microbial ecological environment in livestock gut is constructed by the interaction between intestinal microbiome and hosts.Intestinal microorganisms and their metabolites play an important role in host growth,development,nutritional absorption and reproductive performance.The microbial-brain-intestinal axis is a two-way regulatory channel between the central nervous system and intestinal microbes.Metabolomics analysis of microorganisms in intestinal contents or feces can be the supplement of microbial diversity study to further uncover the interaction between gut microbes and hosts.This article reviewed the livestock intestinal microbiome metabolites,the metabonomics research methods of intestinal microbiome,and the effects of intestinal microbial metabolites on the host.It will be helpful to further understand the interaction between microbial metabolites and hosts.