重组人脑利钠肽治疗急性心肌梗死继发心力衰竭老年患者效果及对其心功能影响分析

Effect of Recombinant Human Brain Natriuretic Peptide in the Treatment of Elderly Patients with Acute Myocardial Infarction Secondary to Heart Failure and Its Effect on Cardiac Function

目的:分析重组人脑利钠肽治疗急性心肌梗死继发心力衰竭老年患者效果及对其心功能影响。方法:选择某院2015年10月~2018年10月收治的80例急性心肌梗死继发心力衰竭患者作为研究对象,随机分为对照组与观察组各40例,对照组患者使用硝酸甘油,观察组患者在上述治疗方法的前提下,使用重组人脑利纳肽进行注射治疗,比较两组患者治疗前治疗后心功能指标、治疗疗效、治疗前后的肾功能指标。结果:(1)与对照组对比,观察组治疗后LVEF明显更高,LVEDD和LVESD明显更低,数据差异存在统计学意义(P<0.05);和治疗前对比,两组治疗后LVEF明显提高,LVEDD、LVESD明显下降,数据差异存在统计学意义(P<0.05)。(2)观察组治疗疗效可达95%,对照组治疗疗效仅达75%,观察组治疗疗效明显优于对照组,数据差异存在统计学意义(P<0.05)。(3)对照组治疗前后谷丙转氨酶、尿素氮、肌酐水平变化显著(P<0.05);观察组治疗前后谷丙转氨酶、尿素氮、肌酐水平变化无明显差异,不具有统计学意义(P>0.05)。结论:重组人脑利钠肽治疗急性心肌梗死继发心力衰竭老年患者效果满意确切,可以有效地改善患者的心功能,从而提高了治疗有效率,安全可靠,值得广泛应用于急性心肌梗死的治疗中。

Objective:To analyze the effect of recombinant human brain natriuretic peptide in the treatment of elderly patients with acute myocardial infarction secondary to heart failure and its effect on cardiac function.Methods:A total of 80 patients with acute myocardial infarction secondary heart failure admitted to a hospital from October 2015 to October 2018 were selected as the study subjects,and 40 patients in each group were randomly assigned.Patients in the control group were treated with nitroglycerin,while patients in the observation group were injected with recombinant human brain natriuretic peptide on the premise of the above treatment methods.Cardiac function indicators,therapeutic effect,and renal function indicators before and after treatment were compared between the two groups.Results:(1)Compared with the control group,LVEF was significantly higher and LVEDD and LVESD were significantly lower in the observation group after treatment,indicating a statistically significant difference(P<0.05).Compared with the comparison before treatment,LVEF significantly increased and LVEDD and LVESD significantly decreased in the two groups after treatment,with statistically significant differences(P<0.05).(2)The therapeutic effect of the observation group was up to 95%,while that of the control group was only up to 75%.The therapeutic effect of the observation group was significantly better than that of the control group,with statistically significant difference(P<0.05).(3)The levels of alanine aminotransferase,urea nitrogen and creatinine in the control group changed significantly before and after treatment(P<0.05).There was no significant difference in the levels of Alt,urea nitrogen and creatinine in the observation group before and after treatment,with no statistical significance(P>0.05).Conclusion:The effect of recombinant human brain natriuretic peptide in the treatment of acute myocardial infarction secondary to heart failure in elderly patients is satisfactory,and can effectively improve the cardiac function of patients,thus improving the treatment efficiency,safe and reliable,worthy of being widely used in the treatment of acute myocardial infarction.