精神科门诊分离[转换]性障碍用药研究

Study of medication among outpatients with dissociative[conversion]disorders

目的了解和分析精神科门诊分离[转换]性障碍患者的用药规律。方法收集2018年7月22日至2019年7月22日该院精神科门诊信息系统数据库中174例临床诊断为分离[转换]性障碍(ICD-10编码为F44)患者的信息,统计分析其治疗药物、药物种类、剂量、频率和联合用药情况。结果174例患者中女164例(94.25%),年龄35~<55岁85例(48.85%),比例最高。接受药物治疗156例(89.66%),其中药物使用频率前3位依次为丙戊酸镁[55例(35.26%)]、奥氮平[53例(33.97%)]、喹硫平[36例(23.08%)];按药理属性使用频率前3位依此为抗精神病药[132例(84.62%)]、镇静催眠/抗焦虑药[77例(49.36%)]、心境稳定剂[69例(44.23%)]。抗精神病药与心境稳定剂联合使用频率最高,联合频率最高药物前3位依次为丙戊酸联合喹硫平、丙戊酸联合奥氮平、丙戊酸联合利培酮。结论治疗分离[转换]性障碍的药物以抗精神病药为主,常见抗精神病药与心境稳定剂联合用药。

Objective To understand and analyze the medication rule among the outpatients with dissociative[conversion]disorders.Methods The information in 174 cases of clinically diagnosed as dissociative[conversion]disorders(ICD-10 coding F44)was collected from the hospital information system(HIS)database in a psychiatric hospital from July 22,2018 to July 22,2019 and their situation such as medication,drug category,dose,frequency and combined medication was statistically analyzed.Results Of 174 cases,164 cases(94.25%)were females,85 cases(48.85%)were 35-55 years old,its proportion was the highest.One hundred and fifty six cases(89.66%)received the medication treatment,among them,the top three of use frequencies were magnesium valproate[55(35.26%)],olanzapine[53(33.97%)]and quetiapine[36(23.08%)].Based on the pharmacological property,the top three of use frequency were antipsychotics in 132 cases(84.62%),sedative-hypnotics and antianxietics in 77 cases(49.36%)and mood stabilizers in 69 cases(44.23%).The combined use frequency of antipsychotic drugs and mood stabilizers was the highest and the top three combinations of combined frequency were valproate+quetiapine,valproate+olanzapine and valproate+risperidone.Conclusion The drugs for treating dissociative[conversion]disorders are dominated by the antipsychotic drugs.The combination use of antipsychotics and mood stabilizers is common.