重离子治疗肿瘤的生物学基础研究进展

Progress on the fundamental biological studies for tumor therapy with heavy particles

重离子束以其独特的物理学和生物学特点,作为肿瘤放疗射线极具优势,重离子治疗在临床上取得了良好的疗效,有可能成为一种先进的肿瘤放疗技术。基础生物医学研究的深入有望为重离子治疗肿瘤最佳束流品质的选择提供理论依据,另外,FLASH和GRID等新型放疗技术在重离子治疗中的应用有望进一步提高重离子治疗肿瘤的有效性和安全性。本文就重离子治疗肿瘤相关基础生物学研究进展和尚需解决的问题进行综述。

Due to its unique physical and biological advantages,heavy ion beam has great advantages as tumor radiotherapy ray.Tumor therapy with heavy particles has achieved outstanding clinical outcome and is of the potential to become the most advanced radiotherapy in this century.Fundamental studies on the biological effects are of significance in providing theoretical principle and optimizing beam quality for tumor therapy with heavy particles.Meanwhile,the application of new techniques such as FLASH and GRID in tumor therapy with heavy particles requires fundamental biological studies as well,especially in improving clinical efficacy and security.In this article,we review the progress on the fundamental biological studies for tumor therapy with heavy particles and arouse discussion on the issues necessary for further elucidation.