宫颈鳞癌治疗后2~5年高危型HPV感染状况及其相关因素

High-risk HPV Infection Status During 2 to 5 Years After Treatment in Cervical Squamous Cell Carcinoma and Its Related Factors

[目的]探讨宫颈鳞癌患者治疗后2~5年高危型HPV感染状况,并分析其相关影响因素。[方法]回顾性分析2013年6月至2017年2月在我院接受治疗的宫颈鳞癌患者159例,随访截止至2019年3月。调查患者治疗后2~5年高危型HPV感染状况及其与年龄、临床分期、组织学分级、治疗方法、性生活恢复、避孕套使用的相关性。[结果]①治疗后2~5年高危型HPV感染率为32.1%(51/159)。②高危型HPV阳性者共51例,感染比例最高的型别为51型25.5%(13/51),其他感染型别占比前五位为HPV16/52/53/56/43型。多型感染检出率为40.4%(21/51)。③单因素分析显示宫颈鳞癌患者治疗后是否使用避孕套与高危型HPV感染率有统计学意义(P<0.05)。单因素及多因素分析均显示患者年龄、疾病分期、组织学分级、治疗方案和性生活恢复与高危型HPV感染率无统计学意义相关(P>0.05)。[结论]宫颈鳞癌治后2~5年高危型HPV感染率仍较高。感染比例较高的型别与健康人群、治疗前人群存在差异,而且多型感染率较高。是否使用避孕套是宫颈鳞癌患者治疗后2~5年高危型HPV感染率的主要影响因素。

[Objective]To investigate the status of high-risk HPV(HR-HPV)infection in cervical squamous cell carcinoma patients during 2 to 5 years after treatment and determine its correlative factors.[Methods]One hundred and fifty-nine patients with cervical squamous cancer who were treated in Beijing Obstetrics and Gynecology Hospital from June 2013 to February 2017 were recruited and followed up till March 2019.The relationship of HR-HPV infection with age,stage of disease,treatment regimens,histological grade,sex life and condom use was analyzed.[Results]During 2 to 5 years after treatment,the infection rate of HR-HPV was 32.1%(51/159).HPV51 was most common type in 51 cases infected with HR-HPV(25.5%,13/51),the other types with higher infection rate were HPV16,52,53,56 and 43.The detection rate of polytypic infection was 40.4%(21/51).The univariate analysis showed that not using condom was associated with HR-HPV infection during 2 to 5 years after treatment(P<0.05),while the age,stage of disease,histological grade,treatment regimens and sex life were not correlated with HR-HPV infection(P>0.05).[Conclusion]The HR-HPV infection rate is still high during 2 to 5 years after treatment in cervical squamous cell carcinoma,which is correlated with the not using condom.