摘要
肿瘤组织是由恶性上皮细胞及其周围的基质细胞微环境形成的复杂混合体。在肿瘤的发生发展过程中,肿瘤细胞与肿瘤微环境相互作用相互影响,其中癌相关成纤维细胞(CAF)是肿瘤微环境的重要组成部分。CAF不仅促进肿瘤细胞的增殖与转移、肿瘤微血管生成以及耐药性产生,还能抑制机体的抗肿瘤免疫,从而促进肿瘤的恶性进展。本文简要综述癌相关成纤维细胞的特性及其在调控肿瘤发生发展中的作用。
Tumor tissue is a complex entity of malignant cells and their surrounding stromal cells.In the pro cess of tumor development,tumor cells closely interact with their tumor microenvironment,in which cancer-associ ated fibroblasts(CAF)are one of the important components of tumor microenvironment.CAF can promote the prolif eration and metastasis of tumor cells,tumor microvessel formation,drug resistance,and inhibit the anti-tumor im munity,leading to tumor progression.This article briefly reviewed the characteristics of CAFs and their role in modulating tumor progression.
作者
万令飞
杨慧
葛晨
刘蕴慧
岳文
裴雪涛
阎新龙
WAN Ling-Fei;YANG Hui;GE Chen;LIU Yun-Hui;YUE Wen;PEI Xue-Tao;YAN Xin-Long(College of Life Science and Bioengineering,Beijing University of Technology,Beijing 100124;Stem Cell and Regenerative Medicine Lab,Institute of Health Service and Transfusion Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850;South China Research Center for Stem Cell&Regenerative Medicine,SCIB,Guangzhou 510005,China)
出处
《生物技术通讯》
CAS
2020年第1期75-82,共8页
Letters in Biotechnology
基金
国家自然科学基金(81772617)
北京市教育委员会科技计划一般项目(KM201710005031)。
关键词
癌相关成纤维细胞
肿瘤微环境
靶向治疗
cancer-associated fibroblast
tumor microenvironment
targeted therapy