生物钟基因介导卵巢功能调控的分子机制研究

Molecular Mechanism of Circadian Clock Gene Mediated Regulation of Ovarian Function

地球的自转产生了以24 h为周期的昼夜节律,因此生物的生理过程和行为活动大都呈现一个近似24 h的周期节律改变,以适应环境的不断变化。昼夜节律在整体水平是一个系统性的调控,它的产生、维持和调控依赖于细胞内生物钟基因的震荡型转录翻译负反馈环路。研究表明,生物钟在卵巢动情周期和生殖系统发育过程中发挥重要作用。本篇综述主要阐述了自卵巢生物钟发现后的种种研究成果,包括卵巢生物钟对类固醇激素生成及排卵的影响,生物钟基因对生育能力的影响,以及生物钟调控与女性生殖系统疾病的相关性。

The rotation of the earth produces a circadian rhythm with a 24-hour cycle,so the biological process es and behavioral activities of the organism mostly exhibit a cyclical rhythm change of approximately 24 hours to adapt to the changing environment.The production,maintenance and regulation of circadian rhythm,which depend on the feedback oscillation of the transcription and translation of the clock genes.Multiple studies have shown that clock genes play important roles in the ovarian estrous cycle and reproductive system development.This re view focused on reviewing the results of various studies relating to the ovarian clock,including the effects of ovari an clocks on steroidogenesis,ovulation and fertility,and the correlation between circadian clock regulation and fe male reproductive system diseases.