血小板抗体检测的多中心临床应用调查——基于中国10家单位的2 338例病例对照研究

Clinical Significance of Platelet Antibody Detection Based on Study of 2338 Case from10 Institutions in China

目的 分析血小板抗体检测患者的临床资料,探究血小板抗体与疾病发生之间的关系。方法 收集2018年7月1日~2019年6月30日在全国10家单位进行血小板抗体检测的住院患者人口学、临床和实验室检查资料,并通过统计学分析其与血小板输注无效、胎儿/新生儿血小板减少性紫癜(fetal and neonatal alloimmune thrombocytopenia,FNAIT)、流产与死胎、免疫性血小板减少症的关系。结果 在收集的2 338例患者中,血小板输注无效患者、FNAIT患者、流产与死胎患者及免疫性血小板减少症患者血小板抗体阳性率较未患上述疾病患者(对照组)高。结论 血小板抗体检测在预防和诊断血小板输注无效、FNAIT、流产与死胎、免疫性血小板减少症中均十分重要,应将其纳入上述情况的常规实验室检查中。

Objective To explore the relationship between platelet antibodies and disease symptom,weinvestigatedthe clinical datafromthe detectionof plateletantibodies in 10 institutions of China.Methods The demographic,clinical and laboratory data of patients who were detectedin platelet antibodies in 10 institutions across the country from July 1,2018 to June 30,2019 were collected and statistically analyzed for platelet transfusion refractory.Relationship between Fetal and neonatal alloimmune thrombocytopenia(FNAIT),abortion and stillbirth,and immune thrombocytopenia.Results Among the 2338 patients,the positive rate of platelet antibody in patients with platelet transfusion refractory,FNAIT patients,abortion and stillbirth patients,and immune thrombocytopenia was higher than that in patients without the above disease(control group).Conclusion Platelet antibody detection is important in the prevention and diagnosis of platelet transfusion refractory,FNAIT,abortion and stillbirth,and immune thrombocytopenia.It should be included in the routine laboratory examination of the above diseases.