慢性阻塞性肺疾病患者血清Galectin-3、IL-38水平与肺功能相关性研究

Correlation Analysis of Serum Galectin-3,IL-38 Levels with Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease

目的 探讨慢性阻塞性肺疾病患者血清半乳糖凝集素-3(Galectin-3)、白介素-38(IL-38)水平变化及与肺功能的相关性。方法 选取本院2016年1月~2018年4月诊治的258例慢性阻塞性肺疾病患者为观察组,其中急性加重期患者(急性组)151例,稳定期患者(稳定组)107例;选取同期129例健康体检者为对照组。入组时检测研究对象血清Galectin-3、IL-38、CRP、PCT水平及肺功能,分析血清Galectin-3、IL-38、CRP、PCT水平与肺功能的相关性。应用ROC曲线分析血清Galectin-3、IL-38、PCT水平对慢性阻塞性肺疾病急性加重期的诊断价值。结果 急性组和稳定组患者血清Galectin-3、IL-38、CRP、PCT水平均高于对照组(P<0.05),且急性组高于稳定组(P<0.05);急性组和稳定组患者PEF% pred、FEV1% pred及FEV1/FVC水平均低于对照组(P<0.05),且急性组低于稳定组(P<0.05)。血清Galectin-3、IL-38、CRP、PCT水平与肺功能指标(PEF% perd、FEV1% pred、FEV1/FVC)呈负相关。ROC曲线分析显示,血清Galectin-3、IL-38诊断COPD急性加重期的曲线下面积(AUC)分别为0.839、0.893,敏感度分别为0.808、0.781,特异度分别为0.841、0.748。血清Galectin-3、IL-38诊断COPD急性加重期的AUC、灵敏度和特异度均高于CRP(AUC:0.735,灵敏度:0722,特异度:0.710)和PCT(AUC:0.760,灵敏度:0.702,特异度:0.682)。结论 COPD患者血清Galectin-3、IL-38、CRP、PCT水平显著上升,并且与肺功能存在一定的关系,可作为COPD患者病情判断的标志物;但血清Galectin-3、IL-38在COPD急性加重期的诊断价值优于CRP和PCT。

Objective To investigate the changes of serum galectin-3 and IL-38 levels in patients with chronic obstructive pulmonary disease(COPD)and their correlation with pulmonary function.Methods From January 2016 to April 2018,151 patients with acute exacerbation of COPD were selected as acute group,107 stable COPD patients and 129 healthy people in the same period were selected as stable group and control group.Serum Galectin-3,IL-38,CRP and PCT levels and lung function were measured at the time of enrollment.Pearson correlation was used to analyze the correlation among serum Galectin-3,IL-38,CRP and PCT levels and lung function.Results The serum levels of Galectin-3,IL-38,CRP and PCT were higher in acute group and stable group than in control group(P<0.05).The serum levels of Galectin-3,IL-38,CRP and PCT in acute group were higher than those in the stable group(P<0.05).The levels of PEF%pred,FEV1%pred and FEV1/FVC in acute group and stable group were lower than those of in control group(P<0.05),and the levels of PEF%pred,FEV1%pred and FEV1/FVC in acute group were lower than those in stable group(P<0.05).Serum Galectin-3,IL-38,CRP and PCT levels were negatively correlated with pulmonary function indices(PEF%perd,FEV1%pred,FEV1/FVC,P<0.05).ROC curve analysis showed that the area under curve(AUC)of serum Galectin-3 and IL-38 in the diagnosis of acute exacerbation of COPD was 0.839 and 0.893,the sensitivity was 0.808 and 0.781,and the specificity was respectively 0.841 and 0.748.The AUC,sensitivity and specificity of serum Galectin-3 and IL-38 in the diagnosis of acute exacerbation of COPD were higher than those of CRP(AUC:0.735,sensitivity:0.722,specificity:0.710)and PCT(AUC:0.760,sensitivity:0.702,specificity:0.682).Conclusion Serum Galectin-3 and IL-38 levels increased significantly in COPD patients,which were closely related to lung function.And serum Galectin-3 and IL-38 could be used as a biological marker for estimating the severity of COPD.However,the diagnostic value of serum Galectin-3 and IL-38 in acute exacerbation of COPD are better than that of CRP and PCT.