抑郁症与血清常量元素、微量元素水平变化关系的病例对照研究

Association of Macro-and Trace-Elements with Depression:A Case-Control Study

目的 探讨抑郁症患者血清常量元素(钙、镁)、微量元素(铜、铁、锰、硒、锌)水平变化及其相关性。方法 收集本院抑郁症患者250例(观察组)及同期年龄、性别匹配的健康自愿者250例(对照组)作为研究对象,采用原子吸收光谱法测定血清常量元素及微量元素含量,并进行数据统计。结果 观察组血清钙、镁、铁、锰、硒及锌含量均高于对照组(P<0.05),而观察组血清铜含量则低于对照组(P<0.05);相关性分析发现,观察组中,锰与镁(r=0.168,P=0.011)、镁与硒(r=0.157,P=0.014)呈正相关,锰与锌(r=-0.187,P=0.006)、锰与铜(r=-0.164,P=0.008)、铜与硒(r=-0.152,P=0.007)呈负相关;在对照组中,锰与镁(r=0.281,P<0.001)呈正相关,锰与铜(r=-0.284,P<0.001)、铜与镁(r=-0.624,P<0.001)呈负相关。结论 常量元素及微量元素变化可能参与抑郁症的发病机制,它们作为抑郁症的独立危险因素可用于疾病的预后评估。

Objective To investigate the association of serum level of macro-elements(calcium and magnesium)and trace elements(copper,iron,manganese,selenium,and zinc)with depression of patients.Methods Two hundred and forty seven patients were enrolled and 248 healthy volunteers,matched by age and sex,were taken as control.The serum levels of macro-minerals and trace elements were detected by atomic absorption spectroscopy.Statistical analysis was performed with independent sample t-tests and Pearson's correlation test.Results Significantly decreased concentrations of calcium and magnesium,iron,manganese,selenium,and zinc were found(P<0.05),while copper notably increased(P<0.05)in the depressive patients compared with the control.Positive correlations of Mn with Mg(r=0.168,P=0.011)and Mg with Se(r=0.157,P=0.014)were seen in patients while negative correlations of Mn with Zn(r=-0.187,P=0.006),Mn with Cu(r=-0.164,P=0.008),and Cu with Se(r=-0.152,P=0.007)were noted.The persons in the control group showed significant positive correlations of Mn with Mg(r=0.281,P<0.001)but negative correlations of Mn with Cu(r=-0.284,P<0.001)and Cu with Mg(r=-0.624,P<0.001).Conclusion Our study suggests that altered serum concentrations of macro-minerals and trace elements are major factors that may contribute to the pathogenesis of depression and may help for assessment of depression risk.