宫颈癌组织中Cep55与FoxM1蛋白表达与临床病理特征及预后的相关性分析

Correlation between Cep55 and FoxM1 protein expression and clinicopathological features and prognosis in cervical cancer

目的:分析宫颈癌组织中心相关蛋白Cep55(Cep55)与叉头转录因子(FoxM1)蛋白的表达情况,并探讨Cep55与FoxM1蛋白在宫颈癌组织中的临床病理特征及预后的相关性。方法:选取本院2010年1月至2013年4月收治的124例宫颈癌患者作为研究对象,采用回顾性分析法分析所有患者的临床及随访资料,根据其资料结果收集124例宫颈癌患者的124份癌组织标本(研究组)及124份其他良性宫颈疾病的正常组织标本(对照组)作为研究对象,所有组织标本均行Cep55与FoxM1蛋白的检测,分析宫颈癌组织中Cep55与FoxM1蛋白的表达与患者临床病理特征和预后的关系。结果:(1)宫颈癌组织中Cep55及FoxM1蛋白阳性表达率分为75.00%(93/124)、77.42%(96/124)(P<0.05);(2)Cep55及FoxM1的表达与宫颈癌患者的年龄、病理类型及累及阴道残端情况均无明显关系(P>0.05);Cep55及FoxM1的表达与宫颈癌患者淋巴结转移、FIGO分期、分化程度及肌层浸润深度有显著相关(P<0.05);(3)经单因素分析得出:FIGOⅡ期、低分化、肌层浸润深度≥1/2及Cep55及FoxM1蛋白阳性患者其生存时间均显著缩短(P<0.05);(4)经多因素Cox比例风险回归模型分析得出:FIGOⅡ期、低分化、肌层浸润深度≥1/2及Cep55及FoxM1蛋白阳性均为影响宫颈癌患者预后的独立危险因素(P<0.05)。结论:Cep55及FoxM1蛋白在宫颈癌癌变组织中以高水平表达,随着患者FIGOⅡ期、低分化、肌层浸润深度≥1/2,其高表达率均上升,且联合FIGOⅡ期、低分化、肌层浸润深度≥1/2共同为影响宫颈癌患者预后的独立危险因素。

Objective:To investigate expression of centrosomal protein(Cep55)and forkhead transcription factor(FoxM1)in cervical cancer tissue,and to analyze its correlation with clinicopathological features and prognosis.Methods:The clinical data and the follow-up data of 124 patients with cervical cancer admitted to our hospital from January 2010 to April 2013 were retrospectively analyzed.The Cep55 and FoxM1 protein expression in the cancer tissues(study group,n=124)and adjacent normal tissues(control group,n=124)were detected.Then the relationships between expression levels and clinicopathological features and prognosis were analyzed.Results:(1)The positive expression rates of Cep55 and FoxM1 protein in cervical cancer tissues were 75.00%(93/124)and 77.42%(96/124)respectively(P<0.05).(2)The expression of Cep55 and FoxM1 were not correlated with age,pathological type and vaginal involvement of cervical cancer patients(P>0.05),while related with the lymph node metastasis,FIGO stage,differentiation degree and depth of myometrial invasion in cervical cancer patients(P<0.05).(3)Univariate analysis showed that the survival time of patients with FIGOII stage,poor differentiation,myometrial invasion depth≥1/2 and positive Cep55 and FoxM1 protein were significantly shorter(P<0.05).(4)The multivariate Cox proportional hazards regression model showed that FIGO II stage,poor differentiation,depth of myometrial invasion≥1/2,and positive Cep55 and FoxM1 protein were independent risk factors for the prognosis of patients with cervical cancer(P<0.05).Conclusion:Cep55 and FoxM1 proteins are expressed at high levels in cervical cancerous tissues,which are even higher among patients with FIGO II stage,poor differentiation,and myometrial invasion depth≥1/2,since these factors are independent risk factors for the prognosis of patients with cervical cancer.