雷公藤多苷片联合环磷酰胺治疗自身免疫性溶血性贫血的临床研究

Effect of tripterysium glycosides combined with cyclophosphamide in treatment of autoimmune hemolytic anemia

目的:研究雷公藤多苷片联合环磷酰胺治疗自身免疫性溶血性贫血的疗效。方法:选取我院2014年12月至2017年12月收治的80例自身免疫性溶血性贫血患者作为研究对象,随机分为两组,每组各40例。对照组给予环磷酰胺,观察组患者患者在此基础上每日给予雷公藤多苷片。比较两组患者在治疗后的临床疗效、复发率和不良反应的发生率以及在治疗前后疾病相关指标水平。结果:经过治疗后,两组患者疾病控制率相比较,观察组显著高于对照组,差异具有统计学意义(P<0.05);在治疗一年后,两组患者疾病复发率相比较,观察组显著低于对照组,差异具有统计学意义(P<0.05);两组患者的LDH、TBil和MCH水平显著优于治疗前,差异具有统计学意义(P<0.05);观察组各项指标改善程度显著优于对照组,差异具有统计学意义(P<0.05)。结论:采用雷公藤多苷片联合环磷酰胺治疗自身免疫性溶血性贫血,具有较好的临床疗效,能够有效缓解并改善患者临床症状,降低治疗后复发,改善患者疾病相关指标,安全性较高,值得临床推广。

Objective:To study the effect of tripterysium glycosides combined with cyclophosphamide in treatment of autoimmune hemolytic anemia.Methods:The 120 patients with autoimmune hemolytic anemia from December2014 to December 2017 were selected and randomly divided into two groups,60 in each group.The control group was given cyclophosphamide.The treatment group was given tripterysium glycosides combined with cyclophosphamide.The treatment effect,recurrence rate and incidence of adverse reactions after treatment were compared;The serum correlation index before and after treatment were compared.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).The recurrence rate of the observation group was significantly lower than that of the control group.The difference between the two groups was statistically significant(P<0.05)one year after treatment.The levels of LDH,TBil and MCH in the two groups were significantly higher than those before treatment.The difference between the two groups was statistically significant(P<0.05).The improvement of the observation group was significantly higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion:Tripterysium glycosides combined with cyclophosphamide treating autoimmune hemolytic anemia has good clinical curative effect,and can significantly improve the patient’s clinical symptoms and reduce recurrence after treatment.It is worthy for clinical promotion for its safety.