ACVR2A与子痫前期相关性研究进展

Research Progress on the Correlation between ACVR2A and Pre-Eclampsia

子痫前期是一种妊娠特异性疾病,是孕产妇和围生期死亡的主要原因。至今尚无任何一种假说可以彻底地解释子痫前期的病理变化,目前比较公认的特征是早期胎盘滋养细胞浸润和螺旋动脉重铸减少。ACVR2A(activin A receptor type 2A)是转化生长因子β(TGF-β)受体家族的成员,被认为是生殖功能的重要调节因子,尤其是在蜕膜化、滋养细胞浸润和胎盘形成过程中起重要作用。近些年的研究表明激活素A及其受体在子痫前期的发生、发展过程中有重要的调控作用。综述ACVR2A与子痫前期的关系,旨在为子痫前期的发病机制、早期诊断及治疗提供新的理论依据。

Pre-eclampsia is a pregnancy-specific disease and a leading cause of maternal and perinatal death.Until now,no hypothesis can fully explain the pathological changes of pre-eclampsia,which is characterized by early placental trophoblast infiltration and decreased spiral artery remodeling.ACVR2A(activin A receptor type 2A),a member of the transforming growth factorβ(TGF-β)receptor family,is considered as an important regulator of reproductive function,especially in the process of decidualization,trophoblast cell infiltration and placental formation.Recent studies have shown that activin A and its receptor play an important regulatory role in the occurrence and development of pre-eclampsia.This paper reviews the relationship between ACVR2A and pre-eclampsia,aiming to provide a new theoretical basis for the pathogenesis,early diagnosis and treatment of pre-eclampsia.