MicroRNA在心肌梗死后左心室重塑和心力衰竭发展中的研究现状

MicroRNA in Development of Left Ventricular Remodeling and Heart Failure after Myocardial Infarction

心肌梗死及梗死后心室重塑明显增加患者病死率,目前大量的研究都在探索各种可能导致心肌梗死后心室重塑的病理生理机制,发现部分新的生物标志物是心肌梗死后心肌重构以及心功能不全的预测因子。近年来,越来越多研究证实microRNA是这一病理过程的重要信号标志,它的各种亚型均能在正常人的血液中检测到,并处于平衡稳定的状态。当患者发生心肌梗死和心力衰竭时,microRNA的不同亚型表达水平可出现明显的变化,因此,不断有研究试图阐释这一变化能否进一步预测心肌梗死后心室重塑和心力衰竭,现做一总结。

Myocardial infarction and post-infarction ventricular remodeling significantly increase the patient mortality rate.Therefore,a large number of studies are currently exploring various pathophysiological mechanisms that may lead to ventricular remodeling after myocardial infarction.Some new biomarkers are found to be the predictors of post-infarction myocardial remodeling and cardiac insufficiency.In recent years,more and more studies have confirmed that microRNA is an important signal marker of this pathological process,and its various subtypes can be detected in normal human blood and in a state of equilibrium and stability.When patients have myocardial infarction and heart failure,the expression levels of different subtypes of microRNA may change greatly.Therefore,there are continuous studies trying to explain whether this change can further predict ventricular remodeling and heart failure after myocardial infarction.This article will make a summary.