中性粒细胞/淋巴细胞比值与干燥综合征患者肺动脉压力的相关性研究

Relationship Between Neutrophil/lymphocyte Ratio and Pulmonary Artery Pressure in Patients with Sjogren’s Syndrome

目的探讨中性粒细胞/淋巴细胞比值(NLR)与干燥综合征(SS)患者肺动脉压力的相关性。方法回顾性分析98例SS患者,根据肺动脉压力分为肺动脉高压组18例和非肺动脉高压组80例。比较两组患者临床特征和实验室检查指标,采用Spearman相关性分析分析NLR与SS患者肺动脉压力的相关性,采用多因素分析探讨SS患者肺动脉压力和肺动脉高压的相关因素。行受试者工作特征曲线分析,探讨NLR预测SS患者发生肺动脉高压的最佳界值。结果两组患者C反应蛋白、白细胞计数、中性粒细胞计数、NLR、红细胞计数、血红蛋白和总胆固醇水平比较,差异有统计学意义(P<0.05)。Spearman相关性分析结果显示,NLR水平与SS患者肺动脉压力呈正相关(r=0.881,P<0.05)。多元线性回归分析结果显示,NLR与SS患者肺动脉压力相关(β=4.812,95%CI 3.581~6.043,P<0.05)。多因素logistic回归分析结果显示,NLR(OR 1.817,95%CI 1.009~3.272,P=0.047)和C反应蛋白(OR 1.302,95%CI 1.086~1.561,P=0.004)均与SS患者肺动脉高压有关(P<0.05)。受试者工作特征曲线分析显示NLR截断值为2.33时对SS患者发生肺动脉高压有较好的预测(灵敏度为84.2%,特异度为61%)。结论NLR与SS患者肺动脉压力有关,且NLR水平对SS患者肺动脉高压具有一定的预测价值。

Objective To investigate the correlation between neutrophil/lymphocyte ratio and pulmonary artery pressure in patients with Sjogren s syndrome.Methods A retrospective analysis of 98 patients with Sjogren s syndrome was performed according to pulmonary artery pressure in 18 patients with pulmonary arterial hypertension and 80 patients with non-pulmonary arterial hypertension.Clinical features and laboratory examination results of the two groups were compared.The correlation between neutrophil/lymphocyte ratio and pulmonary artery pressure in patients with Sjogren s syndrome was analyzed by Spearman correlation.Multivariate analysis was used to investigate the related factors of pulmonary artery pressure and pulmonary hypertension in patients with Sjogren s syndrome.Receiver operator characteristic(ROC)curve analysis was performed to investigate the optimal cut-off point of NLR in predicting pulmonary hypertension in patients with Sjogren s syndrome.Results There were statistically significant differences of C-reactive protein(CRP),WBC,neutrophil count,NLR,RBC,HGB,TC between the two groups(P<0.05).Spearman correlation analysis showed that NLR levels were positively correlated with pulmonary artery pressure in patients with Sjogren s syndrome(r=0.881,P<0.05).Multiple linear regression analysis showed that NLR was associated with pulmonary artery pressure in patients with Sjogren s syndrome(β=4.812,95%CI 3.581~6.043,P<0.05).Multivariate logistic regression analysis showed that NLR(OR 1.817,95%CI 1.009~3.272,P=0.047)and CRP(OR 1.302,95%CI 1.086~1.561,P=0.004)were associated with pulmonary arterial hypertension in patients with Sjogren s syndrome(P<0.05).ROC curve analysis showed that the NLR cut-off value of 2.33 had a good prediction of pulmonary hypertension in patients with Sjogren s syndrome(the sensitivity was 84.2%and the specificity was 61%).Conclusion NLR is associated with pulmonary artery pressure in patients with Sjogren s syndrome,and NLR levels have predictive value for pulmonary arterial hypertension in patients with Sjogren s syndrome.