摘要
The high pharmaceutical cost and multi-drug resistance in tumor therapeutic agents hinder the further application of chemotherapy in tumor therapy.Artificial modified nucleic acid aptamers have the advantages of high binding affinity,programmability,and easy synthesis.Thus,the rational design of artificial modified aptamers is expected to provide a versatile platform for the optimization of chemotherapy agents.In this review,we summarize the modification strategies and the application of the artificial modified nucleotide-containing aptamers,aiming to provide a promising step toward aptamer-related chemotherapeutic agents.
基金
Supported by the National Natural Science Foundation of China(Nos.21904037,21675120)
the National Key R&D Program of China(No.2017YFA0208000).
