摘要
In spite of great development in nanoparticle-based drug delivery systems(DDSs)for improved therapeutic efficacy,it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells.In this work,we report a triangle DNA origami as targeted DDS for cancer therapy.DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h.In addition,the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox)into targeted cancer cell due to their targeting function,reducing side effects associated with nonspecific distribution.Moreover,we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro.Accordingly,this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.
基金
Supported by the National Natural Science Foundation of China(No.21722502)
the National Key R&D Program of China(No.2017YFC0906600)
the National Key Research and Development Program of China for International Science&Innovation Cooperation Major Project between Govemments(No.2018YFE0113200)
the Shanghai Rising-star Program,China(No.l9QA1403000)
the Foundation of the Shanghai Science and Technology Committee,China(No.18490740500).
