乙型肝炎诊断中患者实施血清中免疫球蛋白检验的效果观察及IgA水平影响分析

Observation on the effect of immunoglobulin detection in patients'serum and impact analysis of IgA levels in the diagnosis of hepatitis B

目的探讨乙型肝炎诊断中患者实施血清中免疫球蛋白检验的效果观察及IgA水平影响分析。方法选取2018年9月~2019年3月收治的110例乙型肝炎患者作为本次的研究对象,根据病情的严重程度分为研究A组(慢性轻型乙型肝炎50例)、研究B组(慢性重型乙型肝炎60例),另选取50例健康人群为对照组,并比较三组的血清免疫球蛋白(IgA、M、G)的浓度。另根据乙型肝炎患者的病情恢复情况划分为非改善组、改善组,并将两组的血清免疫球蛋白(IgA、M、G)、TBIL、PTA浓度进行比较。结果研究A组的IgA为(2.24±1.09)g/L、IgM为(2.12±0.52)g/L、IgG为(14.35±3.56)g/L,均低于研究B组的(2.73±1.12)g/L、IgM为(2.73±0.27)g/L、IgG为(17.90±3.69)g/L,差异有统计学意义(P<0.05)。不仅如此,改善组IgA、IgG、IgM、PTA、TBIL指标分别为(2.01±0.34)g/L、(13.12±4.23)g/L、(1.94±0.20)g/L、(26.22±12.13)%及(165.91±100.59)μmol/L,均低于非改善组,差异有统计学意义(P<0.05)。结论对于乙型肝炎患者采取血清球蛋白检测具有较好的效果,可对肝脏细胞的受损程度进行有效判断,以此提高诊断的准确性,可为临床中疾病的治疗提供依据,可推广实施。

Objective To investigate the effect of immunoglobulin detection in patients’serum and impact analysis of IgA levels in the diagnosis of hepatitis B.Methods 110 patients with hepatitis B admitted to our hospital from September 2018 to March 2019 were selected as the subjects of this study.According to the severity of the disease,they were divided into study group A(50 patients of chronic mild hepatitis B)and study group B(60 patients of chronic severe hepatitis B).Another 50 healthy people were selected as the control group.The concentration of serum immunoglobulin(IgA,M,G)of patients in three groups were compared.In addition,the patients with hepatitis B were divided into non-improved group and improved group according to the recovery status.The concentrations of serum immunoglobulin(IgA,M,G),TBIL and PTA of patients in the two groups were compared.Results The IgA of study group A was(2.24±1.09)g/L,IgM was(2.12±0.52)g/L,and IgG was(14.35±3.56)g/L,all of which were lower than those of study group B[IgA:(2.73±1.12)g/L,IgM:(2.73±0.27)g/L,IgG:(17.90±3.69)g/L],and the differences were statistically significant(P<0.05).Moreover,the IgA,IgG,IgM,PTA,and TBIL of patients in the improved group were(2.01±0.34)g/L,(13.12±4.23)g/L,(1.94±0.20)g/L,(26.22±12.13)%and(165.91±100.59)μmol/L,respectively,all of which were lower than those of patients in the non-improved group,and the differences were statistically significant(P<0.05).Conclusion For patients with hepatitis B,serum immunoglobulin detection has a good effect,can effectively determine the degree of liver cell damage,thereby improving the accuracy of diagnosis,and can also provide a basis for the treatment of clinical diseases.Therefore,it can be promoted and implemented.