急性心肌梗死患者血清标志物水平与疾病严重程度的关系研究

The relationship between the expression level of hs-CRP,H-FABP,CKMB and the severity of acute myocardial infarction

目的:探讨急性心肌梗死患者血清标志物水平与疾病严重程度的关系。方法:2018年4月-2019年5月收治急性心肌梗死患者50例作为研究组,选取同期健康志愿者50例作为对照组。分别测定两组血清标志物[C反应蛋白(hs-CRP)、心型脂肪酸结合蛋白(H-FABP)和肌酸激酶同工酶(CKMB)]水平并比较差异。结果:研究组hs-CRP、H-FABP和CKMB水平显著高于对照组,差异有统计学意义(P<0.05)。急性心肌梗死患者hs-CRP、H-FABP和CKMB水平与梗死范围呈正相关,差异有统计学意义(P<0.05)。结论:急性心肌梗死患者发病时hs-CRP、H-FABP和CKMB等标志物可用于判断病情严重程度、评估预后,有一定应用价值。

Objective:To explore the relationship between the expression level of hs-CRP,H-FABP,CKMB and the severity of acute myocardial infarction.Methods:From April 2018 to May 2019,50 patients with acute myocardial infarction were selected as the study group and 50 healthy volunteers were selected as the control group.We measured the levels of serum markers and compared the differences.Results:In the study group,the levels of hs-CRP,H-FABP and CKMB were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The levels of hs-CRP,H-FABP and CKMB in patients with acute myocardial infarction were positively correlated with the infarct size,the difference was statistically significant(P<0.05).Conclusion:At the onset of acute myocardial infarction,the markers such as hs-CRP,H-FABP and CKMB can be used to judge the severity of the disease and evaluate the prognosis,it has certain application value.