D-二聚体含量检测在不同类型胰腺炎诊断中的价值

Diagnostic value of D-dimer level in different types of pancreatitis

目的探讨D-二聚体(DD)含量检测在不同类型胰腺炎诊断中的价值。方法选取急性胰腺炎患者60例,其中轻症胰腺炎患者40例(轻症组)、重症胰腺炎患者20例(重症组),同时选取健康志愿者60名作为对照组,检测各组DD、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)。结果重症组入院时DD、PT、APTT、TT明显高于轻症组和对照组(P<0.05);轻症组入院时DD、PT、APTT、TT明显高于对照组(P<0.05);轻症组和重症组入院后3 d DD、PT、APTT、TT较入院时明显升高(P<0.05),其中轻症组入院后7 d各指标有所降低(P<0.05),而重症组持续升高(P<0.05);重症组入院时、入院后3 d、入院后7 d DD、PT、APTT、TT明显高于轻症组(P<0.05);入院时DD、PT、APTT、TT判断急性胰腺炎严重程度的受试者工作特征(ROC)曲线下面积分别为0.866、0.801、0.776和0.835(P<0.05)。结论DD、PT、APTT、TT检测在急性胰腺炎早期诊断中有一定的应用价值,有助于评估患者病情。

Objective To investigate the diagnostic value of D-dimer(DD)level in different types of pancreatitis.Methods Totally,60 patients with acute pancreatitis were enrolled,and there were 40 cases of mild pancreatitis(mild group)and 20 cases of severe pancreatitis(severe group).A total of 60 healthy subjects were enrolled as control group.The levels of DD,prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)were determined.Results The DD,PT,APTT and TT in severe group at admission were higher than those in mild group and control group(P<0.05).The DD,PT,APTT and TT in mild group at admission were higher than those in control group(P<0.05).The levels of DD,PT,APTT and TT in mild and severe groups at 3 d after admission were higher than those at admission(P<0.05),and those at 7 d after admission in mild group were decreased(P<0.05),while those in severe group continued to increase(P<0.05).In severe group,DD,PT,APTT and TT at admission and 3 d,7 d after admission were higher than those in mild group(P<0.05).The areas under receiver operating characteristic(ROC)curves of DD,PT,APTT and TT at admission in judging the severity of acute pancreatitis were 0.866,0.801,0.776 and 0.835,respectively(P<0.05).Conclusions DD,PT,APTT and TT determinations play roles in the early diagnosis of acute pancreatitis and the assessment of disease severity.