421例早中期妊娠孕妇血清中维生素D及微量元素水平分析

Levels of serum vitamin D and trace elements in 421 pregnant women in early and middle trimester of pregnancy

目的分析早中期妊娠孕妇血清中维生素D及微量元素水平。方法回顾性分析2016年2月—2017年11月于某妇幼保健所进行产前检查的421例孕妇临床资料,孕早期组271例,孕中期组150例。抽取两组孕妇空腹肘静脉血,采用酶联免疫吸附法检测血清25-羟基维生素D水平,采用全自动生化分析仪检测血清微量元素含量。比较两组孕妇维生素D及微量元素水平、维生素D摄入状况。结果孕早期女性维生素D(27.57±6.23)nmol/L及钙水平为(1.62±0.18)nmol/L,均低于孕中期(28.25±6.07)nmol/L、(1.63±0.16)nmol/L,血清镁水平为(1.49±0.25)nmol/L、铁水平为(7.87±0.37)nmol/L,均高于孕中期(1.39±0.27)nmol/L、(7.79±0.41)nmol/L,差异有统计学意义(P<0.05);孕早期维生素D缺乏率为24.72%,高于孕中期15.33%,孕中期维生素D摄入不足率为70.00%,高于孕早期59.04%,差异有统计学意义(P<0.05)。结论与孕中期孕妇相比,孕早期孕妇维生素D缺乏现象较为严重,而微量元素水平基本一致。

Objective To analyze the levels of vitamin D and trace elements in serum of pregnant women in early and second trimester of pregnancy.Methods The clinical data of 421 pregnant women who underwent antenatal examina tion in a maternal and child health care center from February 2016 to November 2017 were collected and analyzed retrospec tively.There were 271 pregnant women in the early pregnancy group and 150 pregnant women in the second trimester of pregnancy group.The serum level of 25 hydroxyvitamin D was measured by enzyme linked immunosorbent assay(ELISA)and the contents of trace elements in serum were detected by the automatic biochemical analyzer.The levels of vitamin D and trace elements,and the intake of vitamin D were compared between two groups.Results In the early pregnancy group,the average level of vitamin D was(27.57±6.23)nmol/L and the average level of calcium was(1.62±0.18)nmol/L,which were lower than those in the second trimester of pregnancy group[(28.25±6.07)nmol/L and(63±0.16)nmol/L];in the early preg nancy group,the average level of magnesium was(1.49±0.25)nmol/L and the average level of ferrum was(7.87±0.37)nmol/L,which were higher than those in the second trimester of pregnancy group[(1.39±0.27)nmol/L and(7.79±0.41)nmol/L],and there were significant differences between two groups(all P<0.05).In the early pregnancy group,the vitamin D deficiency rate was 24.72%,which was higher than that in the second trimester of pregnancy group(15.33%);the rate of insufficient vitamin D intake in the second trimester of pregnancy group was 70.00%,which was higher than that in the early pregnancy group,and there was a significant difference between two groups(P<0.05).Conclusion Compared with the pregnant women in the second trimester of pregnancy,the vitamin D deficiency is more serious in the early pregnant women,but the level of trace elements is at basically the same.