介入联合放射治疗与介入治疗原发性大/巨大肝癌的临床对比研究

Clinical Comparison between Interventional Therapy Combined with Radiotherapy and Interventional Therapy for Primary Large/Giant Liver Cancer

目的:探索介入联合放射治疗在原发性大/巨大肝癌患者中的临床效果.方法:选取笔者所在医院2015年2月-2016年3月诊治的原发性大/巨大肝癌患者118例为研究对象,随机分入两组,各59例.对照组给予肝动脉化疗栓塞介入术,观察组在此基础上给予三维适形放疗,对比两组近期疗效等.结果:观察组近期有效率为57.63%,高于对照组的38.98%(P<0.05);观察组不良反应发生率为13.56%,对照组不良反应发生率为10.17%,差异无统计学意义(P>0.05);观察组治疗后1年生存率为91.53%,对照组治疗后1年生存率为88.14%,差异无统计学意义(P>0.05);观察组治疗后2、3年生存率均高于对照组(P<0.05).结论:将肝动脉化疗栓塞介入术联合三维适形放疗用于原发性大/巨大肝癌治疗中的效果确切,能够杀灭肿瘤细胞,抑制肿瘤细胞增殖,且安全性高,利于延长患者生存期,值得推广.

Objective:To explore the clinical effect of interventional therapy combined with radiotherapy in patients with primary large/giant liver cancer.Method:From February 2015 to March 2016,118 patients with primary large/giant liver cancer diagnosed and treated in our hospital were selected as subjects and randomly divided into two groups,59 cases in each group.The control group was given transcatheter arterial chemoembolization,and the observation group was given three-dimensional conformal radiationtherapy on this basis,the recent efficacy and so on were compared between the two groups.Result:The recent effective rate of the observation group was 57.63%,which was higher than 38.98%of the control group(P<0.05).The incidence of adverse reactions in the observation group was 13.56%,and the incidence of adverse reactions in the control group was 10.17%,and the difference was not statistically significant(P>0.05).The 1-year survival rate after treatment in the observation group was 91.53%,and the 1-year survival rate after treatment in the control group was 88.14%,and the difference was not statistically significant(P>0.05).The 2 and 3-year survival rates after treatment in the observation group were higher than those of the control group(P<0.05).Conclusion:Transcatheter arterial chemoembolization combined with three-dimensional conformal radiationtherapy in the treatment of primary large/giant liver cancer has a definite effect.It can kill tumor cells,inhibit the proliferation of tumor cells,and has a high safety,which is conducive to prolong the survival period.It is worth popularizing.