麻杏石甘汤加减治疗慢性阻塞性肺疾病急性发作的临床效果

Clinical Effect of Modified Maxing Shigan Decoction on Acute Attack of Chronic Obstructive Pulmonary Disease

目的:探讨麻杏石甘汤加减治疗慢性阻塞性肺疾病急性发作的临床效果。方法:选择笔者所在医院2017年2月-2018年9月收治的慢性阻塞性肺疾病急性发作患者60例。随机分为两组,西药组采取常规药物治疗,中西医治疗组则采取常规药物+麻杏石甘汤加减治疗。比较两组治疗效果,喘息、气短、咳嗽、咳痰症状消失时间,治疗前后患者中医证候积分、第1秒用力呼气容积(FEV1)、用力肺活量(FVC),不良反应。结果:中西医治疗组治疗总有效率高于西药组,喘息、气短、咳嗽、咳痰症状消失时间均早于西药组,中医证候积分低于西药组,FEV1、FVC均高于西药组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:常规药物联合麻杏石甘汤加减治疗慢性阻塞性肺疾病急性发作可获得较好预后,可改善患者的肺功能和症状,无明显不良反应。

Objective:To investigate the clinical efficacy of modified Maxing Shigan Decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Method:Sixty patients with acute exacerbation of chronic obstructive pulmonary disease from February 2017 to September 2018 in our hospital were enrolled.They were randomly divided into two groups,the western medicine group was treated with conventional medicine,and the Chinese and western medicine treatment group was treated with conventional medicine combined modified Maxing Shigan Decoction.The treatment efficiency of the two groups,the time of wheezing,shortness of breath,cough,and cough symptoms disappeared,TCM syndrome scores before and after treatment,forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),adverse reactions was compared.Result:The total effective rate of treatment in the Chinese and western treatment group was higher than that in the western medicine group,the disappearance time of wheezing,shortness of breath,cough and expectoration symptoms were earlier than those in the western medicine group,and the TCM syndrome score was lower than that in the western medicine group,and the FEV 1 and FVC were all higher than those in the western medicine group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The conventional drug combined modified Maxing Shigan Decoction can improve the prognosis of acute exacerbation of chronic obstructive pulmonary disease,which can improve the lung function and symptoms of patients without obvious adverse reactions.