靶向治疗联合放化疗同步治疗在肺癌脑转移患者中的临床效果研究

The Clinical Effect of Targeted Therapy Combined with Radiotherapy and Chemotherapy in Patients with Brain Metastasis of Lung Cancer

目的:研究靶向治疗联合放化疗同步治疗在肺癌脑转移患者中的效果。方法:选取2016年2月-2018年7月笔者所在医院收治的84例肺癌脑转移患者,按就诊先后分成观察组(n=42)与对照组(n=42),对照组采用放化疗同步治疗,观察组采用靶向治疗联合放化疗同步治疗,观察两组治疗效果及不良反应情况、1年生存率、局部复发率、远处转移率。结果:观察组治疗总有效率(97.62%)高于对照组(83.33%),不良反应发生率(9.52%)低于对照组(26.19%),差异均有统计学意义(P<0.05);观察组1年生存率(54.76%)高于对照组(19.05%),局部复发率(9.52%)低于对照组(35.71%),远处转移率(7.14%)低于对照组(28.57%),差异均有统计学意义(P<0.05)。结论:靶向治疗联合放化疗同步治疗在肺癌脑转移患者的应用,有效提升治疗效果,可减少不良反应,提高治疗安全性,临床应用价值高。

Objective:To study the effect of targeted therapy combined with radiotherapy and chemotherapy in patients with brain metastasis in lung cancer.Method:From February 2016 to July 2018,84 patients with brain metastasis from lung cancer were selected,and were divided into the observation group(n=42)and the control group(n=42).The control group was treated with radiotherapy and chemotherapy simultaneously,and the observation group was treated with targeted therapy combined with radiotherapy and chemotherapy simultaneously.The therapeutic effect and adverse reactions,1-year survival rate,local recurrence rate and distant metastasis rate of the two groups were observed.Result:The total effective rate(97.62%)in the observation group was higher than that in the control group(83.33%),the incidence of adverse reactions(9.52%)in the observation group was lower than that in the control group(26.19%),the differences were statistically significant(P<0.05).The 1-year survival rate(54.76%)in the observation group was higher than that in the control group(19.05%),the local recurrence rate(9.52%)in the observation group was lower than that in the control group(35.71%),and the distant recurrence rate(7.14%)in the observation group was lower than that of the control group(28.57%),the differences were statistically significant(P<0.05).Conclusion:Targeted therapy combined with concurrent radiotherapy and chemotherapy in the treatment of brain metastasis of lung cancer can effectively improve the treatment effect,reduce adverse reactions,improve the safety of treatment,and has high clinical application value.