吸入用布地奈德混悬液雾化治疗小儿哮喘急性发作效果及对肺功能的影响

Effect of Atomization Inhalation of Budesonide Suspension for Inhalation in the Treatment of Acute Attack of Asthma in Children and Its Effect on Pulmonary Function

目的:探讨吸入用布地奈德混悬液雾化治疗小儿哮喘急性发作效果及对肺功能的影响.方法:选取2018年1月-2019年4月笔者所在医院小儿哮喘急性发作患儿100例,随机分为两组,每组50例.常规组采取常规平喘、祛痰、抗感染等治疗,雾化组在常规组基础上采用吸入用布地奈德混悬液雾化治疗.比较两组治疗效果、急性哮喘发作控制时间、喘息消失时间、呼吸困难消失时间、咳嗽消失时间、治疗前后肺活量、第1秒用力呼气容积、呼气峰流速及不良反应.结果:雾化组总有效率高于常规组,差异有统计学意义(P<0.05).雾化组急性哮喘发作控制时间、喘息消失时间、呼吸困难消失时间、咳嗽消失时间均早于常规组,差异均有统计学意义(P<0.05).雾化组治疗后肺活量、第1秒用力呼气容积、呼气峰流速均高于常规组,差异均有统计学意义(P<0.05).两组不良反应发生率比较,差异均无统计学意义(P>0.05).结论:针对小儿哮喘急性发作患儿,在常规平喘、祛痰、抗感染基础上联合吸入用布地奈德混悬液雾化治疗的效果良好,可显著改善病情,缩短症状消失时间,控制疾病进展和改善肺功能,安全性高.

Objective:To explore the effect of atomization inhalation of Budesonide Suspension for Inhalation in the treatment of acute attack of asthma in children and its effect on pulmonary function.Method:A total of 100 children with acute attack of asthma in our hospital from January 2018 to April 2019 were randomly divided into two groups,50 cases in each group.The routine group was treated with routine antiasthmatic,expectorant,anti-infection,while the atomization group was treated with atomization inhalation of Budesonide Suspension for Inhalation on the basis of the routine group.Treatment effect,control time of acute asthma attack,time of disappearance of wheezing,time of disappearance of dyspnea,time of disappearance of cough,lung capacity,forced expiratory volume in the first second,expiratory peak velocity before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the atomization group was higher than that of the routine group,and the difference was statistically significant(P<0.05).The control time of acute asthma attack,time of disappearance of wheezing,time of disappearance of dyspnea,time of disappearance of cough in the atomization group were earlier than those of the routine group,and the differences were statistically significant(P<0.05).The lung capacity,forced expiratory volume in the first second,expiratory peak velocity after treatment in the atomization group were higher than those of the routine group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions was compared between the two groups,and the difference was not statistically significant(P>0.05).Conclusion:For children with acute asthma attack,atomization inhalation of Budesonide Suspension for Inhalation on the basis of routine antiasthmatic,expectorant,anti-infection have good effect,which can significantly improve the condition,shorten the time of disappearance of symptoms,control disease progression and improve pulmonary function,with high safety.