摘要
An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was developed.The process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro lid in-3,2'-oxindoles] in high yields with good to excellent enantio-and diastereoselectivities.
An organocatalytic asymmetric [3+2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was developed.The process enables efficient incorporation of CF3 groups into functionalized spiro [pyrro lid in-3,2’-oxindoles] in high yields with good to excellent enantio-and diastereoselectivities.
基金
supported by the National Natural Science Foundation of China(Nos.21272068,21572056,21801077)
China Postdoctoral Science Foundation(Nos.2017M621382,2018T110355)
Shanghai Sailing Program(No.18YF1406200)
the Fundamental Research Funds for the Central Universities。
