摘要
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulation to form the C/D rings.
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole.Salient feature of the work is the rapid formation of tetracyclic skeleton via a bioinspired [3+2] annulation to form the C/D rings.
基金
supported by the National Natural Science Foundation of China(No.21871013)
the Drug Innovation Major Project(No.2018ZX09711-001-005-005)。
