期刊文献+

Polymeric nanoparticles of poly(2-oxazoline),tannic acid and doxorubicin for controlled release and cancer treatment 被引量:1

Polymeric nanoparticles of poly(2-oxazoline),tannic acid and doxorubicin for controlled release and cancer treatment
原文传递
导出
摘要 A straightforward coassembly strategy was developed for the preparation of polymeric nanoparticles driving by the intermolecular hydrogen bond between neutral poly(2-methyl-2-oxaozline)(PMeOx),tannic acid(TA) and doxorubicin hydrochloride(Dox).The occurrence of the hydrogen-bonding amongst the different functionalities within the formed nanoparticles was verified by infrared(IR) spectroscopy.Scanning electron microscopy(SEM),dynamic light scattering(DLS),UV-vis absorption and photoluminescent measurements indicated the rapid formation of uniform and water dispersible/stable nanoparticles.The relative poor stability of PMeOx-TA-Dox in fetal bovine serum(FBS) solution enabled the rapid separation of Dox and PMeOx-TA,facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy(CLSM).The presented strategy may provide an efficient alternative for the construction of multifunctional nanomedicines. A straightforward coassembly strategy was developed for the preparation of polymeric nanoparticles driving by the intermolecular hydrogen bond between neutral poly(2-methyl-2-oxaozline)(PMeOx),tannic acid(TA) and doxorubicin hydrochloride(Dox).The occurrence of the hydrogen-bonding amongst the different functionalities within the formed nanoparticles was verified by infrared(IR) spectroscopy.Scanning electron microscopy(SEM),dynamic light scattering(DLS),UV-vis absorption and photoluminescent measurements indicated the rapid formation of uniform and water dispersible/stable nanoparticles.The relative poor stability of PMeOx-TA-Dox in fetal bovine serum(FBS) solution enabled the rapid separation of Dox and PMeOx-TA,facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy(CLSM).The presented strategy may provide an efficient alternative for the construction of multifunctional nanomedicines.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第2期501-504,共4页 中国化学快报(英文版)
基金 The financial support of this work from the National Natural Science Foundation of China(No.51673194) Department of Science and Technology of Jilin Province(Nos.20180101196JC and 20180101170JC)。
关键词 POLYMERIC NANOPARTICLE Poly(2-oxazoline) Drug delivery SELF-ASSEMBLY DOXORUBICIN Polymeric nanoparticle Poly(2-oxazoline) Drug delivery Self-assembly Doxorubicin
  • 相关文献

同被引文献4

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部