炎症小体在纤维化疾病中作用的研究进展

Advances in role of inflammasome in fibrotic diseases

炎症小体为多种蛋白质组成的复合体,其激活和随后的炎性细胞因子分泌对于先天免疫防御是必需的,并且在适应性免疫应答中也发挥重要作用。纤维化是慢性炎症发展的最后阶段,是细胞外基质过度沉积的结果,导致组织结构损伤和器官功能出现障碍。近年来,报道了许多炎症小体在纤维化疾病中的研究。该文对炎症小体在纤维化疾病中的作用进行综述,以促进炎症小体相关机制及药物的研究与开发。

The inflammasome—a molecular complex of proteins whose activation and subsequent secretion of inflammatory cytokines are essential for innate immune defense,playing an significant role in adaptive immune responses.Fibrosis is the final stage of the development of chronic inflammation,which is the result of excessive deposition of extracellular matrix,leading to tissue structure damage and organ dysfunction.This paper reviews the role of inflammasome in fibrotic diseases in order to promote the research and development of inflammasome mechanisms and drugs.