两种麻醉方式治疗急性创伤性颅脑损伤效果观察

Effect of two anesthetic methods on acute traumatic craniocerebral injury

目的:对比分析静吸复合麻醉与全凭静脉麻醉在急性创伤性颅脑损伤患者治疗中的效果。方法:选取90例急性创伤性颅脑损伤按照入院顺序分为对照组和观察组各45例,均接受手术治疗,其中对照组给予静吸复合麻醉,观察组给予全凭静脉麻醉。观察并分析两组麻醉效果和恢复情况。结果:观察组平均动脉压(mean arterial pressure,MAP)、心率(heart rate,HR)、血氧饱和度(pulse oxygen saturation,SpO2)在不同时间段无显著变化(P>0.05);观察组拔管、苏醒和自主呼吸恢复时间、不良反应发生率、炎性细胞因子和S100-β蛋白等指标均显著优于对照组(P<0.05)。结论:与静吸复合麻醉进行比较,对急性创伤性颅脑损伤患者实施全凭静脉麻醉效果显著,可以维持更稳定的血流动力学状态,术后恢复速度更快,神经损伤较小。

Objective: To compare the effect of intravenous inhalational anesthesia and total intravenous anesthesia in the treatment of acute traumatic brain injury. Methods: Ninety patients with acute traumatic brain injury were divided into a control group and an observation group with 45 cases each based on the order of admission. The control group was given intravenous-inhalation combined anesthesia while the observation group was given total intravenous anesthesia, and then all the patients were surgically treated. The anesthetic effect and recovery were observed and analyzed. Results: There were no significant changes over time in mean arterial pressure(MAP), heart rate(HR) and pulse oxygen saturation(SpO2) in the observation group(P>0.05). The time for extubation, wake up, spontaneous breathing recovery and the incidence of adverse reactions, the levels of inflammatory cytokines and S100-β protein were significantly better in the observation group than the control group(P<0.05). Conclusion: The use of total intravenous anesthesia for patients with acute traumatic brain injury has a significant effect, can maintain a more stable hemodynamic state, faster recovery after surgery and less nerve damage compared with the intravenous-inhalation combined anesthesia.