血清血管生成素样蛋白-3水平与新疆哈萨克族人群急性冠脉综合征相关性研究

Correlation between serum angiopoietin-like protein-3 level and acute coronary syndrome in population of Xinjiang Kazakh nationality

目的:探讨血清血管生成素样蛋白-3(angiopoietin-like protein 3,ANGPTL3)水平与新疆哈萨克族人群急性冠脉综合征(acute coronary syndrome,ACS)的相关性。方法:选择已被明确诊断为ACS且经冠状动脉造影检查的新疆哈萨克族患者为研究对象,依据Gensini积分将研究对象分为病例组和对照组。结果:与对照组患者相比,病例组患者的空腹血糖水平、空腹胰岛素水平、胰岛素抵抗指数、胰岛素分泌指数和高密度脂蛋白水平没有显著差异,但体质指数和血清ANGPTL3、总胆固醇、三酰甘油、极低密度脂蛋白水平显著更高。病例组患者的Gensini积分与体质指数和ANGPTL3、总胆固醇、极低密度脂蛋白水平均正相关,回归分析显示体质指数为ANGPTL3水平的影响因素。结论:血清ANGPTL3水平增高可能与新疆哈萨克族人群ACS的发生、发展相关,而体质指数是哈萨克族ACS患者ANGPTL3水平的影响因素。

Objective:To investigate the correlation between serum angiopoietin-like protein 3(ANGPTL3)level and acute coronary syndrome(ACS)in population of Kazakh nationality of Xinjiang.Methods:The patients from Kazakh nationality who were diagnosed as ACS and further examined by arteriography were selected as the subjects of study,which were divided into a case group and a control group according to Gensini score.Results:There were no significant differences between the two groups in the levels of fasting blood glucose,fasting insulin and high density lipoprotein,insulin resistance index and insulin secretion index.However,the levels of ANGPTL3,body mass index(BMI),total cholesterol,triacylglycerol,very low density lipoprotein were significantly higher in the case group than the control group.Regression analysis showed that BMI was the influencing factor of ANGPTL3 level.Conclusion:The increase of serum ANGPTL3 level may be related to the occurrence and development of ACS in Xinjiang Kazakh population while the BMI is the influencing factor of ANGPTL3 level in Kazakh ACS patients.