恶性肿瘤患者握力的影响因素分析

Influence Factors of Handgrip Strength in Patients with Malignant Tumors

目的探讨恶性肿瘤患者握力的影响因素,以期为握力在恶性肿瘤患者营养评估中的应用奠定基础。方法采用横断面调查研究方法,收集广西某三级甲等医院肿瘤内科156例恶性肿瘤患者的临床资料,并测量其握力水平、人体测量学指标及实验室指标,使用营养风险筛查-2002(Nutritional Risk Screening-2002,NRS2002)进行营养风险评分,Pearson相关分析握力与营养相关人体测量学指标、实验室指标及NRS2002营养评分的相关性,采用多元线性回归分析恶性肿瘤患者握力的影响因素。结果Pearson相关分析结果显示,恶性肿瘤患者握力水平与身高、体质量、体质指数、臂围、小腿围、血清白蛋白、血红蛋白、血肌酐呈正相关(P<0.05),与NRS2002营养评分呈负相关(P<0.05);多元线性回归分析结果显示,性别、年龄、血清白蛋白及NRS2002营养评分进入回归方程,共解释总变异的66.7%(P<0.05)。结论性别、年龄、血清白蛋白及NRS2002营养评分情况是恶性肿瘤患者握力的影响因素。

Objective To explore the factors affecting the handgrip strength of patients with malignant tumors.Methods A cross-sectional survey was used to collect clinical data of 156 patients with malignant tumors in the Oncology Department of a tertiary grade A hospital in Guangxi Province,and measure their handgrip strength,anthropometric indexes,and laboratory indexes.Nutritional Risk Screening-2002(NRS2002)was used to analyze nutritional risk.Pearson correlation analysis was used to correlate handgrip strength with nutrition-related anthropometric indicators,laboratory tests,and NRS2002 nutrition score and multivariate linear regression to analyze the factors affecting the handgrip strength of patients with malignant tumors.Results The results of Pearson correlation analysis showed that the handgrip strength of patients with malignant tumors was positively correlated with height,weight,body mass index,arm circumference,calf circumference,serum albumin,hemoglobin,and blood creatinine(P<0.05),but negatively with the NRS2002 nutrition score(P<0.05).The results of multiple linear regression analysis showed that gender,age,serum albumin,and NRS2002 nutrition scores entered the regression equation,explaining 66.7%of the total variation(P<0.05).Conclusion Gender,age,serum albumin,and NRS2002 nutrition scores are factors affecting handgrip strength in patients with malignant tumors.