原发性食管黏液表皮样癌2例临床病理分析

Clinicopathological analysis of 2 cases with primary mucoepidermoid carcinoma of the esophagus

探讨原发性食管黏液表皮样癌(mucoepidermoid carcinoma of the esophagus,MECE)的临床病理学特征、免疫表型、鉴别诊断及治疗方法。回顾性分析2例MECE患者的临床病理资料,2例患者年龄分别为58岁和78岁,男和女各1例,均表现为进食梗阻。病变分别位于食管下段和上段,光镜下癌巢由表皮样细胞、中间细胞及黏液细胞构成。免疫表型:表皮样细胞p63(+)、黏液细胞CK7(+)、CD117(-),AB/PAS染色黏液细胞(+)。MECE发病率低,临床表现缺乏特异性,确诊主要依据术后病理组织学形态及免疫组织化学,手术是主要治疗方法。

To investigate the clinical features,pathological characteristics,immunophenotype,differential diagnosis and treatment of primary mucoepidermoid carcinoma of the esophagus(MECE).Clinicopathological data of 2 patients with MECE were retrospectively analyzed.Two cases of MECE occurred in patients at the age of 58 years and 78 years,one male and one female,who both presented with dysphagia.The tumors were located in the upper and lower portions of the esophagus.Microscopically,MECE was characterized by the presence of an mixture of epidermoid,mucus and intermediate cells.Immunophenotype:p63 protein showed positivity in epidermoid cells.Mucus cells demonstrated a immunepositivity with CK7 protein and negative for CD117.AB/PAS stains for mucus cells were positive.MECE has lower incidence and the clinical manifestation is not specific.Pathological features and immunohistochemistry are important diagnostic criteria,and surgery is the main treatment.